Pradeep Y. Ramulu

Evidence-based Criteria for Assessment of Visual Field Reliability.

FL have little impact on reliability in patients with established glaucoma.

Greater Physical Activity Is Associated with Slower Visual Field Loss in Glaucoma.

Increased walking, greater time spent doing moderate-to-vigorous physical activity, and more time spent in nonsedentary activity were associated with slower rates of VF loss in a treated population of patients with glaucoma, with an additional…

Changes in Anterior Segment Morphology and Predictors of Angle Widening after Laser Iridotomy in South Indian Eyes.

In a South Indian population with PACS or PAC/PACG, LPI results in significant anterior chamber angle widening seen on both ASOCT and gonioscopy, although some degree of persistent iridotrabecular contact was present in approximately half…

Gait Implications of Visual Field Damage from Glaucoma.

Glaucoma severity was associated with several gait parameters predictive of higher fall risk in prior studies, particularly measures of stride-to-stride variability.

Five-Year Visual Field Outcomes of the HORIZON Trial.

CS-HMS has a significant effect on VF preservation in glaucoma patients compared with CS alone, reducing the proportion of fast progressors.

The Impact of COVID-19 on Individuals Across the Spectrum of Visual Impairment.

The pandemic might have had a disproportionate impact on the visually impaired, and evidence-based assessments of COVID-19 health outcomes in this population are warranted.

Comparison of New Visual Disturbances after Superior versus Nasal/Temporal Laser Peripheral Iridotomy: A Prospective Randomized Trial.

Laser peripheral iridotomy likely is safe with respect to visual dysphotopsias regardless of location, LPI size, and amount of laser energy used.

Measuring Disability in Glaucoma.

A wide variety of research tools have been used to characterize the disability resulting from glaucoma.

Glaucoma Screening in Nepal: Cup-to-Disc Estimate With Standard Mydriatic Fundus Camera Compared to Portable Nonmydriatic Camera.

A portable, nonmydriatic, fundus camera can facilitate remote evaluation of disc images on par with standard mydriatic fundus photography.

Predicting Visual Disability in Glaucoma With Combinations of Vision Measures.

Vision in glaucoma is a multidimensional construct that can be described by several variably-correlated vision measures. Measuring more than two vision tests does not substantially improve models for activity limitation.

Predictors of Falls per Step and Falls per Year At and Away From Home in Glaucoma.

In this glaucoma population, most falls occurred at home, and the risk of any step resulting in a fall was higher at home.

Locations, Circumstances, and Outcomes of Falls in Patients With Glaucoma.

Glaucoma patients fall mostly in/around the home and demonstrate similar fall circumstances across the spectrum of disease severity, suggesting that current fall prevention interventions, particularly those emphasizing home modification, may be an adequate starting point…

The Effect of Transitioning from SITA Standard to SITA Faster on Visual Field Performance.

Converting to SITA Faster in eyes that were previously followed with SITA Standard led to similar VF performance in mild glaucoma but resulted in higher MD values in moderate and advanced glaucoma.

The Association of Physical Activity with Glaucoma and Related Traits in the UK Biobank.

Higher overall PA level and greater time spent in moderate and vigorous PA were not associated with glaucoma status but were associated with thicker mGCIPL.

Gait and Balance as Predictors and/or Mediators of Falls in Glaucoma.

Although balance and gait measures are associated with fall rates, they do not explain why persons with greater visual field damage fall more frequently, suggesting the importance of other potential factors such as hazard perception.

Association Between Sleep Parameters and Glaucoma in the United States Population: National Health and Nutrition Examination Survey.

This study revealed associations between glaucoma and abnormal sleep duration, sleep latency, and daytime dysfunction; poor sleep parameters may be a risk factor for or a consequence of glaucoma.

Vision Parameters Most Important to Functionality in Glaucoma.

Measures of visual ability are important for several aspects of quality of life and functionality.

Cup-to-Disc Ratio Asymmetry in U.S. Adults: Prevalence and Association with Glaucoma in the 2005-2008 National Health and Nutrition Examination Survey.

Vertical cup-to-disc ratio asymmetry is predictive of prevalent glaucoma, but the PPV remains low even at high degrees of asymmetry.

Quantifying Fall-Related Hazards in the Homes of Persons with Glaucoma.

Multiple home fall hazards were identified in the study population, and hazard numbers were not lower for persons with worse VF damage, suggesting that individuals with more advanced glaucoma do not adapt their homes for safety.

Patterns of Daily Physical Activity across the Spectrum of Visual Field Damage in Glaucoma Patients.

At worse levels of VF damage, glaucoma patients demonstrate shorter, more fragmented bouts of physical activity throughout the day and lower activity levels during typical waking hours, reflecting low physiologic functioning.

Predicting Visual Field Worsening with Longitudinal OCT Data Using a Gated Transformer Network.

Gated transformer network models trained with OCT data may be used to identify VF worsening.

Association Between Visual Field Damage and Gait Dysfunction in Patients With Glaucoma.

At worse levels of baseline VF damage, patients with glaucoma in this study demonstrated an exacerbated decline in walking speeds (ie, stride velocity and cadence), indicating that mobility speeds decrease faster over time in older…

Evaluation of Angle Closure as a Risk Factor for Reduced Corneal Endothelial Cell Density.

In untreated eyes, only mild, clinically insignificant decrement in ECD was noted with angle closure.

Patient-reported Outcomes, Functional Assessment, and Utility Values in Glaucoma.

Standardizing and improving methods of patient-centered data collection and analysis in glaucoma studies are imperative.

Impact of Glaucoma and Dry Eye on Text-Based Searching.

Text-based visual search is slower for glaucoma patients with greater levels of VF loss and dry eye patients with greater self-reported visual difficulty, and these difficulties may contribute to decreased quality of life in these…

Home Self-tonometry Trials Compared with Clinic Tonometry in Patients with Glaucoma.

Self-tonometry provides IOP data that supplements in-clinic tonometry and would not be detectable over daytime in-clinic diurnal curves.

A Practical Guide to the Pregnant and Breastfeeding Patient with Glaucoma.

The Association of Glaucomatous Visual Field Loss and Balance.

Balance was worse in glaucoma patients with greater VF damage under foam surface testing (designed to inhibit proprioceptive contributions to balance) as well as feet-together firm-surface conditions when somatosensory inputs were available.

Factors Predicting a Greater Likelihood of Poor Visual Field Reliability in Glaucoma Patients and Suspects.

FPs, test duration, and FNs are the primary measures predicting if a VF is likely to be reliable, although tests with normal reliability measures may still be unreliable.

Low Sensitivity of the Van Herick Method for Detecting Gonioscopic Angle Closure Independent of Observer Expertise.

VHA, even when performed by experienced ophthalmologists, misses a substantial proportion of angle closure while incorrectly identifying roughly 1 in 8 open-angle eyes as closed.

Patient Acceptance of Sustained Glaucoma Treatment Strategies.

Most glaucoma patients considered sustained drug-delivery modalities acceptable alternatives to IOP-lowering eye drops, but only when they were said to obviate surgery or demonstrate greater efficacy than eye drops.

Impact of the Ability to Divide Attention on Reading Performance in Glaucoma.

Decreased ability to divide attention, indicated by lower BTA scores, is associated with slower reading speeds in glaucoma with reduced CS and VF defects.

Assessing Functional Disability in Glaucoma: The Relative Importance of Central Versus Far Peripheral Visual Fields.

The relative importance of central 24 degrees versus more peripheral VF damage differs across functional domains in patients with glaucoma.

Resolution of Visual Dysphotopsias after Laser Iridotomy: Six-Month Follow-up.

Environmental Features Contributing to Falls in Persons With Vision Impairment: The Role of Home Lighting and Home Hazards.

Fewer home falls were found with better lighting, but not with fewer home hazards. Lighting improvements at home may reduce fall rates in older adults.

Gait in Elderly Glaucoma: Impact of Lighting Conditions, Changes in Lighting, and Fear of Falling.

Patients with more VF damage demonstrate gait degradation in extreme or changing lighting, which is not mediated by FOF.

Reliability of Several Glaucoma Tests in Patients With Boston Type 1 Keratoprosthesis.

The 10-2 visual field and RNFL thickness seem sufficiently repeatable and might allow the detection of glaucoma progression in KPro eyes. Such testing is important, given limited inter-rater agreement regarding the palpation IOP estimate.

Importance and Severity Dependence of Physical Activity by GPS-Tracked Location in Glaucoma Patients.

Restriction of physical activity in more patients with severe glaucoma results mostly from activity restriction outside the home environment.

Evaluating Goldmann Applanation Tonometry Intraocular Pressure Measurement Agreement Between Ophthalmic Technicians and Physicians.

Two physicians measuring the same patient in the same room disagreed by >2 mm Hg in 17% of patients' eyes, and this amount of disagreement was even higher when comparing physicians to certified technicians.

Frequency of Abstracts Presented at Eye and Vision Conferences Being Developed Into Full-Length Publications: A Systematic Review and Meta-analysis.

More than 60% of abstracts presented at eye and vision conferences were not published in full within 2 years of conference presentation.

Patient-Reported Symptoms Demonstrating an Association with Severity of Visual Field Damage in Glaucoma.

Five patient-reported symptoms explain a significant amount of the variance in VF damage.

Management of Anticoagulation and Antiplatelet Therapy in Glaucoma Surgery.

This review article describes current literature on antithrombotic therapy and perioperative thromboembolic risk evaluation based on individual factors.

Early Endophthalmitis Incidence and Risk Factors after Glaucoma Surgery in the Medicare Population from 2016 to 2019.

Compared with cataract surgery, early endophthalmitis incidence was higher for both glaucoma and combined cataract/glaucoma surgeries, with the highest incidence among tube shunts.

The Aravind Pseudoexfoliation Study: 5-Year Postoperative Results. The Effect of Intraocular Lens Choice and Capsular Tension Rings.

In a large-scale, long-term, prospective comparative study of cataract surgery in eyes with uncomplicated PEX, the risks of IOL decentration and PCO were low and comparable to that in control subjects.

The Heritability of Primary Angle Closure Anatomic Traits and Predictors of Angle Closure in South Indian Siblings.

Iris, anterior chamber, and lens parameters may be heritable whereas angle parameters were not.

The Impact of Neighborhood Factors on Physical Activity in Older Adults With Visual Impairment.

Select NFs (poverty share and crime rate) may disproportionately affect physical activity in patients with severe VF loss.

The Impact of Achieving Target Intraocular Pressure on Glaucomatous Retinal Nerve Fiber Layer Thinning in a Treated Clinical Population.

Being above the clinician-set target pressure is associated with more rapid RNFL thinning in suspect, mild, and moderate glaucoma.

Visual Impairment and Real-World Home Physical Activity With Home Environment in an Older Population.

In this study, results demonstrated that home environment features, particularly lighting, may influence home activity metrics in older adults with visual impairment.

Ophthalmology Surgical Assessment of Tube Shunt Glaucoma Surgery.

The tube shunt assessment tool has face validity, content validity, and interobserver reliability, and can be used to assess tube shunt surgery skills. Further studies are required to determine predictive and construct validity.

The American Glaucoma Society 100: Articles with Significant Impact on Clinical Glaucoma Care.

The AGS 100 is a collection of articles judged to have significant clinical impact on glaucoma care. The list will serve as an online educational resource for ophthalmologists in training and in practice.

Comparison of Patient-Reported Functional Recovery From Different Types of Ophthalmic Surgery.

Patients recovering from cataract and glaucoma surgery report reduced function in the postoperative period.

Safety and Efficacy of 0.1% Nepafenac versus 1% Prednisolone Acetate Eye Drops after Laser Peripheral Iridotomy: A Prospective, Randomized Trial.

Nepafenac was noninferior to prednisolone in controlling inflammation after LPI in PACS.

Corneal Endothelium Changes 6 Months after Laser Peripheral Iridotomy: Prospective Study.

Early Postoperative Conjunctival Complications Leading to Exposure of Surgically Implanted CorNeat EverPatch Devices.

The rate of early conjunctival complications leading to exposure of the CorNeat EverPatch was higher than that of irradiated human donor corneal patch grafts.

Characterizing Longitudinal Changes in Fear of Falling and Quality of Life in Patients with Varying Levels of Visual Field Damage.

Patients with glaucoma generally showed worsening of QoL and FoF over time, though the degree of change was modest and not related to the degree of damage at baseline.

Distinguishing Glaucoma, Cataract, and Glaucoma Suspect Based on Visual Symptoms.

Visual symptoms distinguish disease state to a moderate degree in glaucoma, cataract, and glaucoma suspect patients.

Predictors of Short-Term Intraocular Pressure Change after Laser Peripheral Iridotomy: A Prospective Randomized Study.

Neither LPI location nor degree of gonioscopic angle opening was associated with statistically significant change in IOP after LPI.

Evaluation of Angle Closure as a Risk Factor for Reduced Corneal Endothelial Cell Density.

Clinical Outcomes of Hydrus Microstent Implantation for Open-Angle Glaucoma: Results from a Large Academic Center.

In this nontrial setting, cataract surgery with Hydrus Microstent implantation was associated with sustained reductions in IOP, glaucoma medication burden, and disease progression rate.

A Comparative Analysis of Intraocular Pressure Measurement Accuracy With Reused iCare Probes.

In this prospective comparative analysis, we found that reusing iCare probes up to 5 times does not compromise the accuracy of IOP measurements when disinfected with 70% isopropyl alcohol swabs and ethylene oxide.

Association of Optic Nerve Head and Macular Optical Coherence Tomography Measures With Glaucoma-Related Disability.

OCT RNFL, but not GCIPL, thickness is associated with multiple disability measures independent of VF damage severity.

Intraocular Pressure Control Following Phacoemulsification in Eyes With Pre-existing Aurolab Aqueous Drainage Implant.

In eyes with a pre-existing AADI, phacoemulsification resulted in visual improvement without a significant rise in IOP or increased risk of AADI failure after 2 years follow up.

Neuroprotective Therapies for Patients With Worsening Glaucoma Despite Adequate Intraocular Pressure Lowering-Short-term Neurorecovery, Long-term Neuroprotection?

Reply to Comment on: Evaluating Goldmann Applanation Tonometry Intraocular Pressure Measurement Agreement Between Ophthalmic Technicians and Physicians.

Relationship between home environment features and difficulty in instrumental activities of daily living and other patient-reported measures in persons with glaucoma.

Better home lighting was associated with less frequent difficulty with IADLs (but not FoF or GQL) in a cohort enriched for glaucoma; no associations were noted with any measure for home hazards.

Discrepancy Between Real-World Objective Functioning and Subjective Quality of Life in Visually Impaired Adults.

Female gender, depressive symptoms, and greater visual field damage are associated with greater subjective vision-related disability than predicted by objective functional impairment.

The Impact of Medication Storage Location on Glaucoma Eyedrop Adherence: A Home-Based Assessment Using Electronic Monitoring.

Medication storage location and administration time significantly influence glaucoma medication adherence, while immediate environmental conditions around storage locations were less impactful.

Outcomes of a Physical Activity Intervention in Patients With Glaucoma: A Feasibility Study.

Patients with glaucoma enrolled in a structured PA intervention increased mean PA by at least 50% over 7 weeks, retaining activity for 6 months, with some IOP declines but no VF changes.

Ophthalmological Examination and Imaging Features that Better Predict Risk of Angle Closure in Siblings.

Structural features of eyes with angle closure may assist in stratifying the risk of angle closure in patients' siblings.

Agreement between the ICare HOME Tonometer and the Goldmann Applanation Tonometer in the Assessment of the Peak Intraocular Pressure in the Water-Drinking Test.

Our study demonstrated a high agreement between the ICare HOME and the GAT during the WDT in a clinical environment with supervision.

Reply.

Author Response: Comments on Evaluation of Central and Peripheral Visual Field Concordance in Glaucoma.

Angle Closure Phenotypes in Siblings of Patients at Different Stages of Angle Closure.

Glaucoma Patient Treatment Preferences.

Evaluation of Central and Peripheral Visual Field Concordance in Glaucoma.

Central 24-2 testing generally reflects the extent of damage to the more peripheral VF in glaucoma, although significant disagreement exists for individual eyes.

The Utility of Cap Color and Bottle Characteristics for Topical Glaucoma Therapy.

Ability of Bottle Cap Color to Facilitate Accurate Patient-Physician Communication Regarding Medication Identity in Patients with Glaucoma.

Physician understanding of patient medication use based solely on bottle cap color is frequently incorrect, particularly in patients with glaucoma who may have color vision deficiency.

Use of Various Glaucoma Surgeries and Procedures in Medicare Beneficiaries from 1994 to 2012.

Despite the increase in beneficiaries, the number of glaucoma procedures performed decreased.

Characteristics that Predict Ophthalmic Knowledge among Ophthalmology Residents.

Author Response: Neurological Hemifield Test in Binasal Defects.

Predictors of visual outcomes following Boston type 1 keratoprosthesis implantation.

Glaucoma is the primary reason for loss of visual acuity after KPro implantation.

Severity of vision loss interacts with word-specific features to impact out-loud reading in glaucoma.

Glaucoma patients with greater vision loss make more lexical errors, are slower in reciting longer and less frequently used words, and more slowly transition to new lines of text.

Severity of Vision Loss Interacts with Word-Specific Features to Impact Out-Loud Reading in Glaucoma.

Conclusions: Glaucoma patients with greater vision loss make more lexical errors, are slower in reciting longer and less frequently used words, and more slowly transition to new lines of text.

Combining Frequency Doubling Technology Perimetry and Scanning Laser Polarimetry for Glaucoma Detection.

The multivariable model including GDx-TSNIT, NAP-FDT, and the interaction GDx-TSNIT×NAP-FDT provides the best glaucoma prediction compared with all other multivariable and univariable models.