Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer Thickness for Diagnosing Early to Moderate Glaucoma.
Zangalli Camila S, Jammal Alessandro A, Reis Alexandre S C, Ayub Gabriel, Diniz-Filho Alberto, Paranhos Augusto, Paula Jayter S, Costa Vital P
AI Summary
This study compared MRW and RNFLT for early/moderate glaucoma diagnosis, finding both measurements offer comparable diagnostic performance, suggesting their similar utility in clinical practice.
Abstract
Prcis: In a cross-sectional study from a Brazilian multiracial population, minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness measurements from OCT showed comparable diagnostic performance in discriminating early to moderate glaucoma from healthy eyes.
Purpose
The purpose of this study is to compare the ability of MRW and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements in discriminating early to moderate glaucoma from healthy eyes in a Brazilian population.
Methods
A total of 155 healthy controls and 118 patients with mild to moderate glaucoma (mean deviation >-12 dB) underwent MRW and RNFLT measurements with optical coherence tomography. Only 1 eye per patient was included in the analysis. A receiver operating characteristic (ROC) regression model was used to evaluate the diagnostic accuracy of MRW and RNFLT, whereas adjusting for age and Bruch membrane opening area. Sensitivities at fixed specificities of 95% were calculated for each parameter.
Results
Global RNFLT and MRW showed comparable area under the ROC curves [0.93 (0.91-0.96) and 0.93 (0.89-0.96), respectively; P =0.973]. Both parameters had similar sensitivities (75% vs. 74%, respectively; P =0.852) at a fixed specificity of 95%. The best sector for diagnosing glaucoma for both parameters was the temporal inferior sector, which showed an area under the ROC curve of 0.93 (0.87-0.96) for RNFLT and 0.91 (0.86-0.95) for MRW ( P =0.320). The temporal inferior sector showed similar sensitivities for RNFLT and MRW measurements (83% vs. 77%, respectively) at a fixed specificity of 95% (P =0.230).
Conclusions
MRW and RNFLT measurements showed comparable diagnostic performance in discriminating early to moderate glaucoma from healthy eyes in a Brazilian multiracial population.
MeSH Terms
Shields Classification
Key Concepts5
Minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements, obtained via optical coherence tomography, demonstrated comparable diagnostic performance in distinguishing early to moderate glaucoma from healthy eyes in a Brazilian multiracial population.
Global RNFLT and MRW measurements showed comparable area under the receiver operating characteristic (ROC) curves [0.93 (0.91-0.96) and 0.93 (0.89-0.96), respectively; P =0.973] for diagnosing early to moderate glaucoma in a Brazilian multiracial population.
Global RNFLT and MRW measurements had similar sensitivities (75% vs. 74%, respectively; P =0.852) at a fixed specificity of 95% for diagnosing early to moderate glaucoma in a Brazilian multiracial population.
The temporal inferior sector was identified as the best sector for diagnosing glaucoma for both RNFLT and MRW parameters, showing an area under the ROC curve of 0.93 (0.87-0.96) for RNFLT and 0.91 (0.86-0.95) for MRW (P =0.320) in a Brazilian multiracial population.
The temporal inferior sector showed similar sensitivities for RNFLT and MRW measurements (83% vs. 77%, respectively) at a fixed specificity of 95% (P =0.230) for diagnosing early to moderate glaucoma in a Brazilian multiracial population.
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