Reference values for trans-laminar cribrosa pressure difference and its association with systemic biometric factors.
Pang Ruiqi, Lin Danting, Di Xiaomeng, Liu Xinyu, Gao Lehong, Chen Jia, Jia Yu, Cao Kai, Ren Tianmin, Cheng Ying
AI Summary
This study established normal trans-laminar cribrosa pressure difference (TLCPD) reference values. A key finding was that lower BMI correlated with higher TLCPD, which is clinically relevant for understanding glaucoma risk factors.
Abstract
Objectives
To provide reference values of trans-laminar cribrosa pressure difference (TLCPD) and reveal the association of TLCPD with systemic biometric factors.
Methods
In this cross-sectional study, 526 quasi-healthy subjects (including 776 eyes) who required lumbar puncture for medical reasons were selected from 4915 neurology inpatients from 2019 to 2022. Patients with any diseases affecting intraocular pressure (IOP) or intracranial pressure (ICP) were excluded. The ICPs of all subjects were obtained by lumbar puncture in the left lateral decubitus position. IOP was measured in the seated position by a handheld iCare tonometer prior to lumbar puncture. TLCPD was calculated by subtracting ICP from IOP. Systemic biometric factors were assessed within 1 h prior to TLCPD measurement.
Results
The TLCPD (mean ± standard deviation) was 4.4 ± 3.6 mmHg, and the 95% reference interval (defined as the 2.5th-97.5th percentiles) of TLCPD was -2.27 to 11.94 mmHg. The 95% reference intervals for IOP and ICP were 10-21 and 6.25-15.44 mmHg, respectively. IOP was correlated with ICP (r = 0.126, p < 0.001). TLCPD was significantly negatively correlated with body mass index (r = -0.086, p = 0.049), whereas it was not associated with age, gender, height, weight, blood pressure, pulse, or waist and hip circumference.
Conclusions
This study provides reference values of TLCPD and establishes clinically applicable reference intervals for normal TLCPD. Based on association analysis, TLCPD is higher in people with lower BMI.
MeSH Terms
Shields Classification
Key Concepts6
The trans-laminar cribrosa pressure difference (TLCPD) in 526 quasi-healthy subjects (776 eyes) had a mean of 4.4 ± 3.6 mmHg.
The 95% reference interval for trans-laminar cribrosa pressure difference (TLCPD) in 526 quasi-healthy subjects (776 eyes) was -2.27 to 11.94 mmHg.
The 95% reference intervals for intraocular pressure (IOP) and intracranial pressure (ICP) in 526 quasi-healthy subjects (776 eyes) were 10-21 mmHg and 6.25-15.44 mmHg, respectively.
Trans-laminar cribrosa pressure difference (TLCPD) was significantly negatively correlated with body mass index (r = -0.086, p = 0.049) in a cross-sectional study of 526 quasi-healthy subjects (776 eyes).
Intraocular pressure (IOP) was correlated with intracranial pressure (ICP) (r = 0.126, p < 0.001) in a cross-sectional study of 526 quasi-healthy subjects (776 eyes).
Trans-laminar cribrosa pressure difference (TLCPD) was not associated with age, gender, height, weight, blood pressure, pulse, or waist and hip circumference in a cross-sectional study of 526 quasi-healthy subjects (776 eyes).
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