Threat to fixation and vision-related quality of life in early open-angle glaucoma - results from the Glaucoma Intensive Treatment Study.
Peters Dorothea, Heijl Anders, Andersson-Geimer Sabina, Aspberg Johan, Lindén Christina, Jóhannesson Gauti, Bengtsson Boel
AI Summary
This study found that visual field damage near fixation in early glaucoma did not significantly impact patients' vision-related quality of life, suggesting early central defects may be well-tolerated.
Abstract
Purpose
To determine the effect of glaucomatous visual field (VF) damage close to the point of fixation, called threat-to-fixation (TTF), on vision-related quality of life (VRQoL) in open-angle glaucoma.
Methods
A total of 239 patients from the Glaucoma Intensive Treatment Study (GITS) were included in this analysis. The second VF of patients with newly diagnosed primarily early glaucoma was evaluated for the presence or absence of TTF. TTF was defined as VF loss including one or more of the four innermost test points depressed at p < 1% in the total deviation probability map of Humphrey 24-2 SITA Standard visual fields. VRQoL was evaluated using Rasch-analysed National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) scores. The correlation between VRQoL and TTF was evaluated using uni- and multivariable regression analyses.
Results
TTF was present in at least one eye in 115 patients (48%); located in the superior hemifield alone in 47% (54 of 115), in the inferior hemifield alone in 23% (27 of 115), and in 30% (34 of 115) in both hemifields. The median Rasch-calibrated NEI VFQ-25 scores were identical when comparing patients with TTF (VRQoL score 66, 95% CI: 23-100) and those with no-TTF (VRQoL score 66, 95% CI: 21-100) (p = 0.925). Neither the presence of TTF (R 2 = -0.004, p = 0.968) nor the location of TTF (R 2 = 0.023, p = 0.103) was significantly correlated to Rasch-calibrated NEI VFQ-25 scores.
Conclusion
The presence of TTF did not influence VRQoL, as measured by the NEI-VFQ-25, in this relatively large group of patients with mainly early glaucoma.
MeSH Terms
Shields Classification
Key Concepts5
The presence of threat-to-fixation (TTF) did not significantly influence vision-related quality of life (VRQoL), as measured by the Rasch-calibrated NEI VFQ-25 scores (p = 0.968), in a cohort of 239 patients with mainly early open-angle glaucoma.
The median Rasch-calibrated NEI VFQ-25 scores were identical (66, 95% CI: 23-100) for patients with threat-to-fixation (TTF) and (66, 95% CI: 21-100) for those without TTF (p = 0.925) in a cohort of 239 patients with mainly early open-angle glaucoma.
Neither the presence of threat-to-fixation (TTF) (R^2 = -0.004, p = 0.968) nor the location of TTF (R^2 = 0.023, p = 0.103) was significantly correlated to Rasch-calibrated NEI VFQ-25 scores in a cohort of 239 patients with mainly early open-angle glaucoma.
Threat-to-fixation (TTF) was defined as visual field (VF) loss including one or more of the four innermost test points depressed at p < 1% in the total deviation probability map of Humphrey 24-2 SITA Standard visual fields.
Threat-to-fixation (TTF) was present in at least one eye in 115 patients (48%) in a cohort of 239 patients with newly diagnosed primarily early glaucoma.
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