Analysis of Variation in Incidence of Optic Disc Hemorrhage According to Seasonal and Temperature Changes.
Jang Mirinae, Kim Young Kook, Jeoung Jin Wook, Park Ki Ho
AI Summary
This study found optic disc hemorrhage incidence increases in colder temperatures, potentially due to higher winter IOP. This suggests temperature-related factors influence glaucoma progression.
Abstract
Purpose
To investigate seasonal variation in optic disc hemorrhage (DH) by review of fundus photographs representative of 2 calendar years (2019 and 2020).
Design
Retrospective, observational trend study.
Methods
Patients who visited the Glaucoma Clinic of Seoul National University Hospital and underwent fundus photography were included. All available stereo disc photographs and red-free retinal nerve fiber layer photographs taken between January 1, 2019 and December 31, 2020 were retrospectively reviewed. The monthly incidence rate of DH was determined by reference to the photographs. Seasonal temperature information and patients' intraocular pressure (IOP) information were obtained, organized, and analyzed.
Results
Fundus images of 13,514 eyes were reviewed, and 454 eyes were confirmed to have DH. Poisson regression analyses revealed that as the temperature (T) increased by 1 °C, the DH risk ratio was reduced to 0.979 (95% confidence interval [CI] 0.969-0.989, P < .01). The DH incidence ratio was 1.53 (95% CI 1.23-1.91, P < .01) for the T <10 °C group relative to the T ≥20 °C group. The IOP of the patients with DH in winter was significantly higher than that measured in summer.
Conclusion
DH is affected by temperature, and as such, shows seasonal variability. This variability is believed to be caused by temperature-related factors such as IOP or hematological factors. © 2022 Elsevier Inc. All rights reserved.
MeSH Terms
Shields Classification
Key Concepts4
In a retrospective observational trend study of 13,514 eyes, the optic disc hemorrhage (DH) risk ratio was reduced to 0.979 (95% confidence interval [CI] 0.969-0.989, P < .01) as the temperature increased by 1 °C.
In a retrospective observational trend study of 13,514 eyes, the optic disc hemorrhage (DH) incidence ratio was 1.53 (95% CI 1.23-1.91, P < .01) for the temperature (T) <10 °C group relative to the T ≥20 °C group.
In a retrospective observational trend study of 13,514 eyes, the intraocular pressure (IOP) of patients with optic disc hemorrhage (DH) in winter was significantly higher than that measured in summer.
Optic disc hemorrhage (DH) is affected by temperature, showing seasonal variability, which is believed to be caused by temperature-related factors such as intraocular pressure or hematological factors, based on a retrospective observational trend study of 13,514 eyes.
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