Outcomes of Partial Versus Complete Goniotomy With or Without Phacoemulsification for Primary Open Angle Glaucoma: A Multicenter Study.
Song Yunhe, Zhu Xiaomin, Zhang Yao, Shu Jing, Dang Guangfu, Zhou Wenzong, Sun Lu, Li Fei, Lin Fengbin, Zhang Yingzhe
AI Summary
This study found partial goniotomy (120°) lowers IOP as effectively as complete (360°) goniotomy, with or without cataract surgery, but causes less hyphema. This suggests partial goniotomy is a safer, effective option.
Abstract
Précis: Goniotomy (GT) 120 degrees with or without phacoemulsification was sufficient to lower the intraocular pressure (IOP) and reduce hyphema for primary open angle glaucoma.
Purpose
To compare the surgical outcomes and safety profiles of 120 degrees and 360 degrees GT with or without phacoemulsification cataract extraction and intraocular lens implantation (PEI) for primary open angle glaucoma.
Patients and methods: This multicenter retrospective study consisted of 139 eyes and was divided into 4 groups: (1) 120 degrees GT, (2) 360 degrees GT, (3) PEI + 120 degrees GT, and (4) PEI + 360 degrees GT. IOP, number of topical hypotensive medications, and complications were recorded and evaluated at baseline and at the final visit. The complete and qualified success rate and their potential associated factors were also investigated. The effectiveness and safety profile of the surgery were compared between different subgroups.
Results
After a mean follow-up of 8.6 months, the IOP reduction was 13.2 ± 8.3 (38.8 ± 28.8%), 12.4 ± 8.3 (41.6 ± 18.2%), 12.8 ± 9.9 (39.4 ± 34.5%), and 13.8 ± 7.2 (46.0±17.1%) mm Hg in 120 degrees, 360 degrees, PEI + 120 degrees GT group, and PEI + 360 degrees GT, respectively. No significant difference was found in IOP, a decline of IOP from baseline, topical hypotensive medication, and complete or qualified success between either standalone 120 degrees versus 360 degrees GT, or PEI + 120 degrees versus PEI + 360 degrees GT (all P s > 0.05). The PEI + 120 degrees GT group had a lower final IOP than the 120 degrees GT group ( P = 0.0002) whereas there was no difference between PEI + 360 degrees GT and 360 degrees GT group ( P = 0.893). Both 360 degrees GT and PEI + 360 degrees GT group had a significantly higher incidence of hyphema than the 120 degrees GT and PEI + 120 degrees GT groups (all P s < 0.0001).
Conclusions
GT of 120 or 360 degrees lowered IOP equally with or without cataract surgery, and hyphema was most commonly noted after complete GT. Partial GT alone or in combination with cataract surgery was an effective and safe approach to manage patients with open angle glaucoma.
MeSH Terms
Shields Classification
Key Concepts6
Goniotomy (GT) 120 degrees with or without phacoemulsification for primary open angle glaucoma was sufficient to lower the intraocular pressure (IOP) and reduce hyphema.
In a multicenter retrospective study of 139 eyes, after a mean follow-up of 8.6 months, the IOP reduction was 13.2 ± 8.3 (38.8 ± 28.8%) mm Hg in the 120 degrees GT group, 12.4 ± 8.3 (41.6 ± 18.2%) mm Hg in the 360 degrees GT group, 12.8 ± 9.9 (39.4 ± 34.5%) mm Hg in the PEI + 120 degrees GT group, and 13.8 ± 7.2 (46.0 ± 17.1%) mm Hg in the PEI + 360 degrees GT group for primary open angle glaucoma.
In a multicenter retrospective study of 139 eyes with primary open angle glaucoma, no significant difference was found in IOP, decline of IOP from baseline, topical hypotensive medication, and complete or qualified success between either standalone 120 degrees versus 360 degrees GT, or PEI + 120 degrees versus PEI + 360 degrees GT (all P's > 0.05).
In a multicenter retrospective study of 139 eyes with primary open angle glaucoma, the PEI + 120 degrees GT group had a lower final IOP than the 120 degrees GT group (P = 0.0002), whereas there was no difference between PEI + 360 degrees GT and 360 degrees GT group (P = 0.893).
In a multicenter retrospective study of 139 eyes with primary open angle glaucoma, both 360 degrees GT and PEI + 360 degrees GT group had a significantly higher incidence of hyphema than the 120 degrees GT and PEI + 120 degrees GT groups (all P's < 0.0001).
Partial goniotomy alone or in combination with cataract surgery was an effective and safe approach to manage patients with open angle glaucoma.
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