A Brillouin microscopy analysis of the crystalline lenses of Chinese adults with myopia.
Ma Yong, Cao Jian, Yu Yanze, Fukuyama Teruko, Bao Yongle, Ding Xuan, Niu Lingling, Zhou Xingtao, Zhao Jing
AI Summary
Brillouin microscopy revealed age-related changes in lens biomechanics and geometry in myopic Chinese adults, correlating with anterior chamber parameters. This offers insights into myopia progression and glaucoma risk.
Abstract
To evaluate lenticular biomechanical and geometric parameters in Chinese adults with myopia and identify relevant factors using Brillouin microscopy (BM) and Pentacam. The biomechanical and geometric properties of the ocular lenses of Chinese adults with myopia were quantified using BM. Anterior segment images were acquired using a Pentacam. Correlated factors including age, sex, spherical equivalent (SE), intraocular pressure (IOP), axial length (AL), white-to-white ratio (WTW), central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) were analyzed. We studied 65 eyes from 65 participants (mean age, 25.23 ± 6.12 years). Width of Top Plateau (WTP), Width of Bottom Plateau (WBP), Slope of Anterior Cortex (SAC), Slope of Posterior Cortex (SPC), and Height of Plateau (Height) metrics obtained using BM showed mean values of 2.597 ± 0.393 mm, 4.310 ± 0.535 mm, 1.344 ± 0.549 GPa/mm, -1.343 ± 0.480 GPa/mm, and 3.373 ± 0.048 GPa, respectively. No significant correlation was found between these parameters and sex, SE, IOP, CCT, ACA, or Height. Interestingly, WBP (r = 0.467, P < 0.001), SAC (r = 0.412, P = 0.001), and SPC (r = -0.280, P = 0.024) were significantly associated with age, and an age-related increase of WBP (slope of 35.36 ± 10.08 μm per year) was identified. Both ACD and ACV showed significant correlations with SAC (r = 0.329 and 0.380, P = 0.008 and 0.002, respectively), but not with SPC. BM provided a novel perspective on lenticular biomechanical and geometric properties in Chinese adults with myopia, which correlated with age, AL, WTW, ACD, and ACV.
MeSH Terms
Shields Classification
Key Concepts5
In Chinese adults with myopia (n=65 eyes from 65 participants, mean age 25.23 ± 6.12 years), the mean values for Width of Top Plateau (WTP), Width of Bottom Plateau (WBP), Slope of Anterior Cortex (SAC), Slope of Posterior Cortex (SPC), and Height of Plateau (Height) metrics obtained using Brillouin microscopy were 2.597 ± 0.393 mm, 4.310 ± 0.535 mm, 1.344 ± 0.549 GPa/mm, -1.343 ± 0.480 GPa/mm, and 3.373 ± 0.048 GPa, respectively.
In Chinese adults with myopia (n=65 eyes from 65 participants), Width of Bottom Plateau (WBP) (r = 0.467, P < 0.001), Slope of Anterior Cortex (SAC) (r = 0.412, P = 0.001), and Slope of Posterior Cortex (SPC) (r = -0.280, P = 0.024) were significantly associated with age, with an age-related increase of WBP (slope of 35.36 ± 10.08 μm per year).
In Chinese adults with myopia (n=65 eyes from 65 participants), Anterior Chamber Depth (ACD) and Anterior Chamber Volume (ACV) showed significant correlations with Slope of Anterior Cortex (SAC) (r = 0.329 and 0.380, P = 0.008 and 0.002, respectively), but not with Slope of Posterior Cortex (SPC).
In Chinese adults with myopia (n=65 eyes from 65 participants), no significant correlation was found between lenticular biomechanical parameters (Width of Top Plateau, Width of Bottom Plateau, Slope of Anterior Cortex, Slope of Posterior Cortex, Height of Plateau) and sex, spherical equivalent, intraocular pressure, central corneal thickness, or anterior chamber angle.
Brillouin microscopy (BM) and Pentacam were used to evaluate lenticular biomechanical and geometric parameters in Chinese adults with myopia.
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