Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia.
Yang Jinpeng, Li Yangjiani, Zhang Qi, Zeng Simei, Huang Haishun, Wu Caiqing, Liu Zhe, Tang Jiahui, Wu Siting, Chen Yuze
AI Summary
Optic nerve shape affects structure-function correspondence in myopic glaucoma, suggesting specific visual field sectors are key for assessing highly myopic glaucoma.
Abstract
Purpose
The purpose of this study was to determine the influence of optic nerve head (ONH) rotation and tilt on the structure-function (S-F) relationship differences between early open-angle glaucoma (OAG) with and without high myopia (HM).
Methods
A total of 164 eyes, including 69 early highly myopic glaucoma (HMG) eyes, 60 early OAG eyes, and 35 healthy HM eyes, were included. All the eyes underwent spectral-domain optical coherence tomography, standard automated perimetry, and fundus photography simultaneously. S-F relationships were analyzed by comparing the peripapillary retinal nerve fiber layer thickness (pRNFLT) to the corresponding visual field sensitivity loss (VFSL) according to the Garway-Heath map. Linear regression analyses were used to evaluate the relationship between ONH rotation and tilt with pRNFLT and VFSL.
Results
Multivariate regression analysis demonstrated that the ovality index was associated with nasal (P = 0.014) pRNFLT in OAG eyes and with nasal (P < 0.001), temporal (P = 0.012), and superior nasal (P = 0.015) pRNFLT in healthy HM eyes, but not in HMG eyes. Moreover, ONH rotation was significantly associated with inferior nasal (P = 0.013) pRNFLT in HMG eyes and with inferior temporal (P = 0.029) and inferior nasal (P = 0.036) pRNFLT in healthy HM eyes, whereas no associations were observed in OAG eyes. The strongest relationship between pRNFLT and VFSL for HMG and OAG were found in the inferior temporal (R = 0.567) and superior temporal sector (R = 0.638), respectively. However, no significant relationships were observed in healthy HM eyes (all P > 0.05).
Conclusions
Optic disc rotation and tilt may affect the distribution of the pRNFL in HM eyes with or without glaucoma, resulting in abnormal correspondence between structure and function. The analysis of the S-F relationship in the inferior temporal sector could be a valuable factor in assessing HMG eyes.
MeSH Terms
Shields Classification
Key Concepts6
In a cross-sectional study of 164 eyes (69 early highly myopic glaucoma (HMG) eyes, 60 early open-angle glaucoma (OAG) eyes, and 35 healthy HM eyes), the ovality index was associated with nasal (P = 0.014) peripapillary retinal nerve fiber layer thickness (pRNFLT) in OAG eyes.
In a cross-sectional study of 164 eyes (69 early highly myopic glaucoma (HMG) eyes, 60 early open-angle glaucoma (OAG) eyes, and 35 healthy HM eyes), the ovality index was associated with nasal (P < 0.001), temporal (P = 0.012), and superior nasal (P = 0.015) peripapillary retinal nerve fiber layer thickness (pRNFLT) in healthy high myopia (HM) eyes.
In a cross-sectional study of 164 eyes (69 early highly myopic glaucoma (HMG) eyes, 60 early open-angle glaucoma (OAG) eyes, and 35 healthy HM eyes), optic nerve head (ONH) rotation was significantly associated with inferior nasal (P = 0.013) peripapillary retinal nerve fiber layer thickness (pRNFLT) in HMG eyes.
In a cross-sectional study of 164 eyes (69 early highly myopic glaucoma (HMG) eyes, 60 early open-angle glaucoma (OAG) eyes, and 35 healthy HM eyes), optic nerve head (ONH) rotation was significantly associated with inferior temporal (P = 0.029) and inferior nasal (P = 0.036) peripapillary retinal nerve fiber layer thickness (pRNFLT) in healthy high myopia (HM) eyes.
In a cross-sectional study of 164 eyes (69 early highly myopic glaucoma (HMG) eyes, 60 early open-angle glaucoma (OAG) eyes, and 35 healthy HM eyes), the strongest relationship between peripapillary retinal nerve fiber layer thickness (pRNFLT) and visual field sensitivity loss (VFSL) for HMG was found in the inferior temporal sector (R = 0.567).
In a cross-sectional study of 164 eyes (69 early highly myopic glaucoma (HMG) eyes, 60 early open-angle glaucoma (OAG) eyes, and 35 healthy HM eyes), the strongest relationship between peripapillary retinal nerve fiber layer thickness (pRNFLT) and visual field sensitivity loss (VFSL) for OAG was found in the superior temporal sector (R = 0.638).
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