Anthocyanin oligomer (grape skin extract) administration improves dry eye disease: A randomised, double-blind, placebo-controlled study.
Fan Meiqi, Kim Su Ah, Choi Young-Jin, Tang Yujiao, Yang Hyun Pil, Kim Eun-Kyung
AI Summary
Grape skin extract (anthocyanin oligomers) safely improved dry eye symptoms, tear stability, and ocular surface health, suggesting a new oral treatment for mild-to-moderate dry eye disease.
Abstract
Background
Dry eye disease is a chronic, progressive ocular disease characterised by ocular discomfort and is one of the most common ophthalmological disorders that affects people's lives.
Methods
This study investigated the clinical efficacy of anthocyanin oligomers (grape skin extract) for the treatment of dry eye. One hundred and eight patients with dry eye were randomly divided into placebo and treatment groups, each with 54 cases. The placebo group received maltodextrin (800 mg/day) and the treatment group received anthocyanin oligomers (800 mg/day). Clinical efficacy, clinical indices, and occurrence of adverse reactions were compared between the two groups.
Results
Anthocyanin oligomers were safe and effective in mild-to-moderate dry eye disease, improving the tear break-up time, intraocular pressure, ocular surface disease, and patient symptomatology.
Conclusions
The use of oral anthocyanin oligomers in the treatment of dry eye patients can enhance the therapeutic effect and improve the quality of life of patients while ensuring the safety of treatment, making this therapeutic option suitable for wider application.
MeSH Terms
Shields Classification
Key Concepts3
Oral anthocyanin oligomers (grape skin extract) at 800 mg/day were safe and effective in mild-to-moderate dry eye disease, improving tear break-up time, intraocular pressure, ocular surface disease, and patient symptomatology.
The administration of oral anthocyanin oligomers (grape skin extract) 800 mg/day in patients with dry eye disease can enhance therapeutic effect and improve patient quality of life, while maintaining treatment safety.
A randomized, double-blind, placebo-controlled study investigated the clinical efficacy of anthocyanin oligomers (grape skin extract) for the treatment of dry eye in 108 patients, comparing an 800 mg/day anthocyanin oligomer group to an 800 mg/day maltodextrin placebo group.
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