Retinal Vascular Fingerprints as Novel Biomarkers for Primary Angle Closure Disease Progression.
Wang Jin, Han Shumei, Mou Dapeng, Tang Xin, Shi Danli, He Mingguang, Guo Chunyan, Wang Ningli, Zhang Ye
AI Summary
Retinal vascular changes distinguish primary angle-closure glaucoma from earlier stages and are independently linked to optic nerve damage, potentially offering new biomarkers for disease progression.
Abstract
Purpose
To evaluate retinal vascular parameters across primary angle-closure disease (PACD) stages and explore their association with glaucomatous optic neuropathy (GON).
Design
A cross-sectional, hospital-based study.
Participants
We enrolled 638 eyes from 425 participants aged ≥40 years with PACD and further classified them into primary angle closure suspect (PACS), primary angle closure (PAC), and primary angle closure glaucoma (PACG) groups.
Methods
Retinal vascular parameters were measured using the Retinal-based Microvascular Health Assessment System and compared between 3 groups. A multivariable logistic mixed effects model was used to identify factors associated with the presence of GON.
Main outcome measures
Vessel caliber, tortuosity, complexity, and branching angle parameters.
Results
No significant differences in retinal vascular parameters were found between PACS and PAC groups. Eyes in PACG showed significant vascular changes compared to PACS ( P < 0.05). Elevated intraocular pressure (odds ratio [OR] = 2.44, P < 0.001), reduced arteriolar curve tortuosity (OR = 0.12, P = 0.002), arteriolar fractal dimension (OR = 0.08, P = 0.027), arteriolar branching angle (OR = 0.16, P = 0.004), and asymmetry ratio (OR = 0.10, P < 0.001 for artery and OR = 0.25, P = 0.023 for vein) were significantly associated with the presence of GON.
Conclusions
Retinal "vascular geometric fingerprints" show significant alterations in eyes with PACG compared to PACS and are independently associated with the presence of GON. These findings offer new insights into the vascular changes in GON, and longitudinal studies are needed to determine their prognostic value and clinical utility in managing PACD.
Financial disclosures: The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Shields Classification
Key Concepts5
Eyes with primary angle closure glaucoma (PACG) showed significant vascular changes compared to primary angle closure suspect (PACS) (P < 0.05) in a cross-sectional study of 638 eyes from 425 participants aged ≥40 years with PACD.
Elevated intraocular pressure (odds ratio [OR] = 2.44, P < 0.001), reduced arteriolar curve tortuosity (OR = 0.12, P = 0.002), arteriolar fractal dimension (OR = 0.08, P = 0.027), arteriolar branching angle (OR = 0.16, P = 0.004), and asymmetry ratio (OR = 0.10, P < 0.001 for artery and OR = 0.25, P = 0.023 for vein) were significantly associated with the presence of glaucomatous optic neuropathy (GON) in a cross-sectional study of 638 eyes from 425 participants aged ≥40 years with PACD.
Retinal "vascular geometric fingerprints" show significant alterations in eyes with primary angle closure glaucoma (PACG) compared to primary angle closure suspect (PACS) and are independently associated with the presence of glaucomatous optic neuropathy (GON) in a cross-sectional study of 638 eyes from 425 participants aged ≥40 years with PACD.
Retinal vascular parameters, including vessel caliber, tortuosity, complexity, and branching angle, were evaluated across primary angle-closure disease (PACD) stages in a cross-sectional, hospital-based study of 638 eyes from 425 participants aged ≥40 years.
No significant differences in retinal vascular parameters were found between primary angle closure suspect (PACS) and primary angle closure (PAC) groups in a cross-sectional study of 638 eyes from 425 participants aged ≥40 years with PACD.
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