Cup-to-Disc Ratio From Heidelberg Retina Tomograph 3 and High-Definition Optical Coherence Tomography Agrees Poorly With Clinical Assessment.
Shamira A Perera, Li Lian Foo, Carol Y L Cheung, John C Allen, Daniel Chua, Yih Chung Tham, Seng Chee Loon, Tien Yin Wong, Tin Aung
Summary
In general, there is poor correlation and a lack of agreement of VCDR measured using HRT-3, HD-OCT, and clinical grading.
Abstract
PURPOSE
To investigate the agreement of vertical cup-to-disc ratio (VCDR) measured from Heidelberg Retina Tomograph 3 (HRT-3), high-definition optical coherence tomography (HD-OCT), and clinical grading.
METHODS
A total of 933 consecutive subjects underwent optic nerve head imaging with HRT-3 and HD-OCT during a single visit. The vertical dimensions of the disc and cup were measured by slit-lamp examination using an eyepiece graticule. Bland-Altman plots evaluated the agreement in the VCDR obtained by the 2 instruments and clinical grading.
RESULTS
We found a significant trend for the difference in VCDR measured clinically and with HRT and HD-OCT (P<0.001 for both). The mean VCDR differed significantly between clinical measurement and that evaluated by HRT and HD-OCT, respectively (0.40 ± 0.12 vs. 0.37 ± 0.21 and 0.40 ± 0.12 vs. 0.50 ± 0.14, P<0.001 for both), with significantly poor correlation (r(2)=0.35 and 0.34, P<0.001 for both).
CONCLUSIONS
In general, there is poor correlation and a lack of agreement of VCDR measured using HRT-3, HD-OCT, and clinical grading. HD-OCT has somewhat better agreement with clinical measurements of VCDR. Compared with clinical grading, HD-OCT tended to overestimate VCDR, whereas HRT-3 tended to underestimate it.
More by Shamira A Perera
View full profile →A Deep Learning System for Automated Angle-Closure Detection in Anterior Segment Optical Coherence Tomography Images.
Efficacy of Phacoemulsification Alone vs Phacoemulsification With Goniosynechialysis in Patients With Primary Angle-Closure Disease: A Randomized Clinical Trial.
Pupillary Responses to Full-Field Chromatic Stimuli Are Reduced in Patients with Early-Stage Primary Open-Angle Glaucoma.
Top Research in Optic Nerve & Disc
Browse all →Efficacy of a Deep Learning System for Detecting Glaucomatous Optic Neuropathy Based on Color Fundus Photographs.
Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma.
Inflammation in Glaucoma: From the back to the front of the eye, and beyond.
Discussion
Comments and discussion will appear here in a future update.