Perera Shamira A

A Deep Learning System for Automated Angle-Closure Detection in Anterior Segment Optical Coherence Tomography Images.

The results demonstrate the potential of the deep learning system for angle-closure detection in AS-OCT images.

Efficacy of Phacoemulsification Alone vs Phacoemulsification With Goniosynechialysis in Patients With Primary Angle-Closure Disease: A Randomized Clinical Trial.

This randomized clinical trial was unable to show that PEI-GSL added additional IOP lowering compared with PEI alone in patients with PACD.

Pupillary Responses to Full-Field Chromatic Stimuli Are Reduced in Patients with Early-Stage Primary Open-Angle Glaucoma.

Patients with early-stage POAG exhibit reduced pupillary responses to moderate and high irradiances of blue and red lights.

The Singapore Asymptomatic Narrow Angles Laser Iridotomy Study: Five-Year Results of a Randomized Controlled Trial.

In patients with bilateral asymptomatic PACS, eyes that underwent prophylactic LPI reached significantly fewer end points compared with control eyes over 5 years. However, the overall incidence of PAC or PACG was low.

Evaluation of the Anterior Segment Angle-to-Angle Scan of Cirrus High-Definition Optical Coherence Tomography and Comparison With Gonioscopy and With the Visante OCT.

The anterior segment angle-to-angle scans of Cirrus HD-OCT demonstrated similar diagnostic performance as Visante in detecting gonioscopic closed angles. The agreement between Cirrus and gonioscopy for detecting eyes with closed angles was moderate.

Visual Field Progression in Patients with Primary Angle-Closure Glaucoma Using Pointwise Linear Regression Analysis.

In patients with PACG being managed in a hospital setting, VF progression was noted in 15.8%, and the overall rate of VF loss was -0.12±0.51 dB/year.

In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans.

We have developed a methodology to assess the biomechanical properties of human ONH tissues in vivo and provide preliminary comparisons in healthy and OHT subjects. Our proposed methodology may be of interest for glaucoma management.

Distinct iris gene expression profiles of primary angle closure glaucoma and primary open angle glaucoma and their interaction with ocular biometric parameters.

Distinct iris gene expression supports the pathophysiological differences that exist between PACG and POAG. Biometric parameters can combine with iris gene expression to more accurately define PACG from POAG.

Association of Functional Loss With the Biomechanical Response of the Optic Nerve Head to Acute Transient Intraocular Pressure Elevations.

The biomechanical response of the ONH to acute IOP elevations was associated with established visual field loss in POAG eyes, but not in primary angle-closure glaucoma eyes.

Optic Nerve Tortuosity and Globe Proptosis in Normal and Glaucoma Subjects.

In this sample, subjects with glaucoma exhibited tauter optic nerves and more protruding eye globes compared with normal eyes. This may impact optic nerve head deformations in anatomically predisposed patients.

Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma.

The proportion of plateau iris was similar across the three ASOCT-based PACG subgroups and more than one-third of subjects with PACG were diagnosed with plateau iris based on standardized UBM criteria.

Characteristics of the Corneal Endothelium Across the Primary Angle Closure Disease Spectrum.

The corneal ECD and morphological characteristics such as CV and hexagonality are not significantly different across the PAC disease spectrum.

Plateau Iris and Severity of Primary Angle Closure Glaucoma.

The higher proportion of plateau iris configuration in eyes with severe PACG compared with early-to-moderate PACG suggest that this may be a contributory factor for disease severity.

Multivariate Normative Comparison, a Novel Method for Improved Use of Retinal Nerve Fiber Layer Thickness to Detect Early Glaucoma.

The multivariate normative database of RNFL showed better glaucoma discrimination capability than conventional age-matched comparisons, suggesting that accounting for demographic and anatomic variance in RNFL thickness may have usefulness in improving glaucoma detection.

Retinal Oximetry in Subjects With Glaucomatous Hemifield Asymmetry.

In our study, localized visual field losses were not associated with changes in retinal oximetry but were associated with narrower retinal arteriolar diameters in PACG and NTG.

Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head.

In our model, the OPA, pulse volume, and ONH deformations decreased with an increasing heart rate, whereas the LC became stiffer.

Development and Validation of a Preference-Based Glaucoma Utility Instrument Using Discrete Choice Experiment.

Use of Glau-U revealed large decrements in utility that were associated with late-stage glaucoma, suggesting that this new instrument may be useful for cost-effectiveness analyses of interventions and informing resource allocation policies for glaucoma and…

Intraocular pressure change after phacoemulsification in angle-closure eyes without medical therapy.

The mean IOP reduction 6 months after phacoemulsification was 20%. Less IOP reduction was observed in the presence of lower preoperative IOP and more extensive PAS.

Three-Dimensional Structural Phenotype of the Optic Nerve Head as a Function of Glaucoma Severity.

This study uncovered complex 3-D structural differences of the ONH in both neural and connective tissues as a function of glaucoma severity.

Altered Iris Aquaporin Expression and Aqueous Humor Osmolality in Glaucoma.

PACG and POAG eyes featured significant increase in AQP1 and AQP2 expression in the iris and reduced aqueous osmolality compared to nonglaucoma eyes.

Oral Ibuprofen is Associated With Reduced Likelihood of Early Bleb Failure After Trabeculectomy in High-Risk Glaucoma Patients.

Early adjunctive oral ibuprofen administered to individuals at high risk of posttrabeculectomy scarring is associated with greater IOP reductions and reduced likelihood of bleb failure.

Investigating the neuroprotective effect of Copolymer-1 in acute primary angle closure - Interim report of a randomized placebo-controlled double-masked clinical trial.

After APAC, there was no difference in VF progression (or RNFL thickness change) between Cop-1 and placebo groups. However, there was improvement of MD in Cop-1 treated patients.

Glaucoma in Older Asians Aged 60 to 100 Years: Prevalence, Factors, Trends, and Projections (2024-2040).

Glaucoma is common among older Singaporeans, with notable sociodemographic and modifiable clinical factors. Rising prevalence among Indians and the projected increase in cases underscore the need for targeted screening and early interventions.

3D Structural Phenotype of the Optic Nerve Head in Glaucoma and Myopia-A Key to Improving Glaucoma Diagnosis in Myopic Populations.

This study demonstrated that ONHs exhibit distinct structural signatures across H, HM, G, and HMG conditions.

Characteristics of Eyes With Asymptomatic Primary Angle Closure Glaucoma With Varying Severity of Visual Field Loss at Presentation.

Similar age at presentation of severe PACG and those with less severe disease suggests that the severe group either developed PACG at an earlier age or underwent rapid disease progression.

3-Year Outcomes of iStent Implant Combined with Phacoemulsification in Asian Eyes with Glaucoma: A Multi-Dimensional Surgical Success Analysis.

Combined iStent and phacoemulsification provided sustained, long-term reductions in both IOP and medication burden over 3 years, with over half achieving success across multiple stringent criteria, supporting its role as an effective, minimally invasive surgical…

Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data.

Our findings on the biomechanics of crypts in the iris may drive the development of novel treatments by altering ABL morphology, providing an alternative bypass for angle closure prevention in high-risk patients.

Biometric Factors Associated With Acute Primary Angle Closure: Comparison of the Affected and Fellow Eye.

Eyes with previous APAC had smaller anterior segment dimensions when compared with their fellow eyes. Iris thickness was the strongest predictor of angle width in both affected and fellow eyes.

Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels.

In this group of clinic-based PACG patients, the superior hemifield was found to be affected more severely than the inferior hemifield, and the differences between them increased with worsening disease severity.

Finite Element Analysis Predicts Large Optic Nerve Head Strains During Horizontal Eye Movements.

Our models predicted high ONH strains during eye movements, which were aggravated with stiffer optic nerve sheaths.

Determinants of pupil diameters and pupil dynamics in an adult Chinese population.

Among normal eyes in an adult Chinese population, SPC was associated with larger baseline PD.

Persistence of Glaucoma Therapy and Visual Field Progression.

There were small but appreciable differences in VF progression rates between persistent and nonpersistent patient eyes on glaucoma drops, but differences were not significant.

Erratum. Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma.

Argon Laser Peripheral Iridoplasty for Primary Angle-Closure Glaucoma: A Randomized Controlled Trial.

After 1 year, ALPI was associated with higher failure rates and lower IOP reduction compared with PGA therapy in eyes with persistent appositional angle closure and raised IOP after LI.

The Impact of Lens Vault on Visual Acuity and Refractive Error: Implications for Management of Primary Angle-closure Glaucoma.

The magnitude of LV was not associated with VA or spherical equivalent. Lens extraction may be a consideration in eyes with angle closure with large LV in the absence of visually significant cataract.

Structural Differences in the Optic Nerve Head of Glaucoma Patients With and Without Disc Hemorrhages.

Eyes with DH consistently displayed both structural features of more advanced glaucoma confirmed simultaneously on planimetry and SD-OCT, with concurrent VF deterioration.

Cup-to-Disc Ratio From Heidelberg Retina Tomograph 3 and High-Definition Optical Coherence Tomography Agrees Poorly With Clinical Assessment.

In general, there is poor correlation and a lack of agreement of VCDR measured using HRT-3, HD-OCT, and clinical grading.

A Genetic Variant in TGFBR3-CDC7 Is Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore.

The presence of the index SNP rs1192415 (TGFBR3-CDC7) was associated with VF progression in POAG patients. These findings warrant further investigation in independent cohorts.

Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma.

Corneal biomechanical parameters measured by the ORA are not associated with severity of glaucoma in PACG.

Pupillary Responses to High-Irradiance Blue Light Correlate with Glaucoma Severity.

In glaucomatous eyes, reduced pupillary responses to high-irradiance blue light were associated with greater visual field loss and optic disc cupping.

Swept-source optical coherence tomography assessment of iris-trabecular contact after phacoemulsification with or without goniosynechialysis in eyes with primary angle closure glaucoma.

Eyes that undergo PE+GSL surgery have a greater reduction in circumferential ITC area than eyes that undergo PE alone.

Evaluation of Choroidal Thickness, Intraocular Pressure, and Serum Osmolality After the Water Drinking Test in Eyes With Primary Angle Closure.

The increase in IOP after WDT was higher in PACG eyes compared to FE-APAC; however, the latter had lower serum osmolality at baseline.

Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects.

Compared to Chinese, Japanese angle-closure eyes have smaller and more crowded anterior segment with thicker lenses.

Efficacy of selective laser trabeculoplasty in primary angle-closure glaucoma: a randomized clinical trial.

Eyes with PAC or PACG respond to SLT in the short term, but the overall long-term therapeutic effectiveness needs further evaluation.

Lamina cribrosa visibility using optical coherence tomography: comparison of devices and effects of image enhancement techniques.

Adaptive compensation is superior to EDI in improving LC visibility. Visibility of the posterior LC remains poor suggesting impracticality in using LC thickness as a glaucoma biomarker.