J GlaucomaMarch 201817 citations

Diagnostic Ability and Structure-function Relationship of Peripapillary Optical Microangiography Measurements in Glaucoma.

Rao Harsha L, Dasari Srilakshmi, Riyazuddin Mohammed, Puttaiah Narendra K, Pradhan Zia S, Weinreb Robert N, Mansouri Kaweh, Webers Carroll A B

View on PubMed DOI: 10.1097/IJG.0000000000000873

AI Summary

This study found peripapillary OMAG measurements had diagnostic ability for glaucoma, with inferior sector OMAG best correlating with RNFL and visual loss, but were less accurate than RNFL thickness.

Abstract

Purpose

The aim of this study was to evaluate the diagnostic abilities of peripapillary optical microangiography (OMAG) measurements in eyes with primary open-angle glaucoma (POAG) and to evaluate the relationship of these measurements with retinal nerve fiber layer (RNFL) thickness and visual sensitivities in different peripapillary sectors.

Methods

In a cross-sectional study, 97 eyes of 57 control subjects and 101 eyes of 66 POAG patients underwent OMAG and RNFL imaging with optical coherence tomography. POAG was diagnosed on the basis of the masked evaluation of optic disc stereo photographs. Area under receiver operating characteristic curves and sensitivities at 90% specificity of the OMAG and RNFL thickness measurements in different peripapillary sectors were evaluated. Association between OMAG, RNFL thickness, and visual sensitivity measurements were evaluated using fractional polynomial regression models.

Results

All OMAG and RNFL measurements were significantly less in the POAG compared with the control eyes. Diagnostic abilities of the best OMAG measurement (inferior sector vessel length density, area under receiver operating characteristic curves: 0.84, sensitivity at 90%, specificity: 65%) were significantly less (P<0.05) than that of the best RNFL measurement (inferior sector RNFL thickness, 0.94 and 81%). Inferior sector vessel length density showed the strongest association with inferior sector RNFL thickness (R=0.66, P<0.001) and the superior sector visual sensitivity loss (R=0.21, P=0.006).

Conclusions

The inferior sector OMAG measurements had the best diagnostic ability in glaucoma and the strongest association with RNFL and the visual sensitivity measurements. Diagnostic ability of OMAG measurements, however, were significantly less than the RNFL thickness measurements.

MeSH Terms

AdultAgedAged, 80 and overAngiographyCase-Control StudiesCross-Sectional StudiesFemaleGlaucoma, Open-AngleHumansIntraocular PressureMaleMiddle AgedOptic DiskPredictive Value of TestsRetinaSensitivity and SpecificityStructure-Activity RelationshipTomography, Optical CoherenceVision Disorders

Shields Classification

Ch. 4Optic Nerve, Retina, and Choroid

Ch. 5Assessment of Visual Fields

Ch. 11Chronic Open-Angle Glaucoma and Normal Tension Glaucoma

Key Concepts5

All peripapillary optical microangiography (OMAG) and retinal nerve fiber layer (RNFL) measurements were significantly less in primary open-angle glaucoma (POAG) eyes compared with control eyes in a cross-sectional study of 101 POAG eyes and 97 control eyes.

DiagnosisCross-sectionalCross-sectional Studyn=101 POAG eyes and 97 control eyesCh5Ch12

The diagnostic abilities of the best peripapillary optical microangiography (OMAG) measurement (inferior sector vessel length density, area under receiver operating characteristic curves: 0.84, sensitivity at 90% specificity: 65%) were significantly less (P<0.05) than that of the best retinal nerve fiber layer (RNFL) measurement (inferior sector RNFL thickness, 0.94 and 81%) in a cross-sectional study of 101 POAG eyes and 97 control eyes.

Comparative EffectivenessCross-sectionalCross-sectional Studyn=101 POAG eyes and 97 control eyesCh5Ch12

Inferior sector vessel length density from peripapillary optical microangiography (OMAG) showed the strongest association with inferior sector retinal nerve fiber layer (RNFL) thickness (R=0.66, P<0.001) and the superior sector visual sensitivity loss (R=0.21, P=0.006) in a cross-sectional study of 101 POAG eyes and 97 control eyes.

MechanismCross-sectionalCross-sectional Studyn=101 POAG eyes and 97 control eyesCh5Ch6Ch7

The inferior sector peripapillary optical microangiography (OMAG) measurements had the best diagnostic ability in glaucoma and the strongest association with retinal nerve fiber layer (RNFL) and visual sensitivity measurements in a cross-sectional study of 101 POAG eyes and 97 control eyes.

DiagnosisCross-sectionalCross-sectional Studyn=101 POAG eyes and 97 control eyesCh5Ch7Ch12

The diagnostic ability of peripapillary optical microangiography (OMAG) measurements were significantly less than the retinal nerve fiber layer (RNFL) thickness measurements for glaucoma diagnosis in a cross-sectional study of 101 POAG eyes and 97 control eyes.