Bozard B Renee

Ganapathy Preethi S, White Richard E, Ha Yonju, Bozard B Renee, McNeil Paul L, Caldwell R William et al.

Homocysteine causes retinal ganglion cell death by activating NMDA receptors, leading to calcium influx and oxidative stress. Blocking NMDA receptors protects these cells, suggesting a potential therapeutic target for glaucoma.

Ganapathy Preethi S, Perry Richard L, Tawfik Amany, Smith Robert M, Perry Elizabeth, Roon Penny et al.

Excess homocysteine dysregulates retinal ganglion cell mitochondrial dynamics, causing increased fission and smaller mitochondria. This finding suggests a novel mechanism for RGC damage in hyperhomocysteinemia-linked neurodegenerative diseases like glaucoma.