Roon Penny

Cui Xuezhi, Navneet Soumya, Wang Jing, Roon Penny, Chen Wei, Xian Ming et al.

This study found that Hhcy mice maintain retinal glutathione/taurine/H2S levels, particularly elevated H2S, despite pathway mutations, suggesting these neuroprotective molecules mitigate glaucoma-related damage.

Wang Jing, Cui Xuezhi, Roon Penny, Smith Sylvia B

Sigma1R activation with (+)-pentazocine protected diabetic mouse retinas, preserving ganglion cells and reducing gliosis, suggesting Sigma1R modulation is a promising neuroprotective strategy for diabetic retinopathy.

Markand Shanu, Saul Alan, Roon Penny, Prasad Puttur, Martin Pamela, Rozen Rima et al.

Mthfr-deficient mice with mild hyperhomocysteinemia showed retinal ganglion cell loss, nerve fiber layer thinning, and mild vasculopathy. This suggests hyperhomocysteinemia may contribute to human neurovasculopathies like glaucoma.

Ganapathy Preethi S, Perry Richard L, Tawfik Amany, Smith Robert M, Perry Elizabeth, Roon Penny et al.

Excess homocysteine dysregulates retinal ganglion cell mitochondrial dynamics, causing increased fission and smaller mitochondria. This finding suggests a novel mechanism for RGC damage in hyperhomocysteinemia-linked neurodegenerative diseases like glaucoma.

Ganapathy Preethi S, Moister Brent, Roon Penny, Mysona Barbara A, Duplantier Jennifer, Dun Ying et al.

Studying CBS mutant mice, elevated retinal homocysteine was found to cause retinal neuron death, particularly in the ganglion cell layer. This suggests homocysteine contributes to glaucoma-like damage.

Umapathy Nagavedi S, Dun Ying, Martin Pamela M, Duplantier Jennifer N, Roon Penny, Prasad Puttur et al.

This study found that System N glutamine transporters (SN1/SN2), crucial for the glutamate-glutamine cycle, are significantly expressed and functional in retinal ganglion cells, not just glia, impacting RGC health and glaucoma.

Smith Sylvia B, Duplantier Jennifer, Dun Ying, Mysona Barbara, Roon Penny, Martin Pamela M et al.

This study found that the sigmaR1 ligand (+)-pentazocine protected retinal architecture and ganglion cells in a diabetic mouse model, suggesting it's a promising neuroprotective therapy for retinal degeneration.

Martin Pamela M, Dun Ying, Mysona Barbara, Ananth Sudha, Roon Penny, Smith Sylvia B et al.

This study found key energy transporters (SMCT1/2) are expressed in specific retinal cells, suggesting their vital, cell-specific roles in retinal metabolism and potential implications for retinal health and disease.

Martin Pamela M, Roon Penny, Van Ells Tracy K, Ganapathy Vadivel, Smith Sylvia B

Diabetic mice showed significant retinal ganglion cell death via apoptosis, suggesting these models are valuable for studying diabetic neuropathy in the eye.