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Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia.
Markand Shanu, Saul Alan, Roon Penny, Prasad Puttur, Martin Pamela, Rozen Rima et al.
Invest Ophthalmol Vis SciApr 201528 citationsBasic Science
Mthfr-deficient mice with mild hyperhomocysteinemia showed retinal ganglion cell loss, nerve fiber layer thinning, and mild vasculopathy. This suggests hyperhomocysteinemia may contribute to human neurovasculopathies like glaucoma.