Ganapathy Vadivel

Markand Shanu, Saul Alan, Roon Penny, Prasad Puttur, Martin Pamela, Rozen Rima et al.

Mthfr-deficient mice with mild hyperhomocysteinemia showed retinal ganglion cell loss, nerve fiber layer thinning, and mild vasculopathy. This suggests hyperhomocysteinemia may contribute to human neurovasculopathies like glaucoma.

Ha Yonju, Saul Alan, Tawfik Amany, Williams Cory, Bollinger Kathryn, Smith Robert et al.

Mice lacking sigma receptor 1 showed late-onset inner retinal dysfunction and optic neuropathy-like changes, suggesting σR1 is crucial for long-term retinal neuroprotection.

Ha Yonju, Dun Ying, Thangaraju Muthusamy, Duplantier Jennifer, Dong Zheng, Liu Kebin et al.

Sigma receptor 1 activation protects retinal neurons from oxidative stress by modulating ER stress pathways, suggesting a potential therapeutic target for diabetic retinopathy.

Umapathy Nagavedi S, Dun Ying, Martin Pamela M, Duplantier Jennifer N, Roon Penny, Prasad Puttur et al.

This study found that System N glutamine transporters (SN1/SN2), crucial for the glutamate-glutamine cycle, are significantly expressed and functional in retinal ganglion cells, not just glia, impacting RGC health and glaucoma.

Smith Sylvia B, Duplantier Jennifer, Dun Ying, Mysona Barbara, Roon Penny, Martin Pamela M et al.

This study found that the sigmaR1 ligand (+)-pentazocine protected retinal architecture and ganglion cells in a diabetic mouse model, suggesting it's a promising neuroprotective therapy for retinal degeneration.

Dun Ying, Thangaraju Muthusamy, Prasad Puttur, Ganapathy Vadivel, Smith Sylvia B

This study found that (+)-pentazocine, a sigmaR1 ligand, protected retinal ganglion cells from excitotoxic death. This suggests sigmaR1 ligands could be a therapeutic strategy for glaucoma and other retinal diseases.

Martin Pamela M, Dun Ying, Mysona Barbara, Ananth Sudha, Roon Penny, Smith Sylvia B et al.

This study found key energy transporters (SMCT1/2) are expressed in specific retinal cells, suggesting their vital, cell-specific roles in retinal metabolism and potential implications for retinal health and disease.

Martin Pamela M, Roon Penny, Van Ells Tracy K, Ganapathy Vadivel, Smith Sylvia B

Diabetic mice showed significant retinal ganglion cell death via apoptosis, suggesting these models are valuable for studying diabetic neuropathy in the eye.