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Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells.
Ganapathy Preethi S, Perry Richard L, Tawfik Amany, Smith Robert M, Perry Elizabeth, Roon Penny et al.
Invest Ophthalmol Vis SciJul 201146 citationsBasic Science
Excess homocysteine dysregulates retinal ganglion cell mitochondrial dynamics, causing increased fission and smaller mitochondria. This finding suggests a novel mechanism for RGC damage in hyperhomocysteinemia-linked neurodegenerative diseases like glaucoma.