Chen John J

Handzic Armin, Xie Jim Shenchu, Tisavipat Nanthaya, O'Cearbhaill Roisin Maire, Tajfirouz Deena A, Chodnicki Kevin D et al.

This study found that in MOG-associated optic neuritis, milder orbital optic nerve enhancement on MRI was associated with poorer visual recovery, suggesting MRI can help predict prognosis.

Sattarova Victoria, Flowers Alexis, Gospe Sidney M, Chen John J, Stunkel Leanne, Bhatti M Tariq et al.

This study found coexisting malignant hypertension and intracranial hypertension can cause severe vision loss. Clinicians should screen for papilledema in patients with very high blood pressure and bilateral optic disc edema.

Bennett Jeffrey L, Costello Fiona, Chen John J, Petzold Axel, Biousse Valérie, Newman Nancy J et al.

This review highlights that optic neuritis subtypes, like those linked to MS or MOGAD, have distinct prognoses. Early, accurate diagnosis guides tailored treatments, improving visual outcomes and preventing severe atrophy.

Liu Alice, Craver Emily C, Bhatti M Tariq, Chen John J

This study found compressive optic neuropathy incidence is 1.14/100,000/year. Earlier treatment significantly improved visual fields, highlighting the need for prompt diagnosis to preserve vision.

Warwick Alexander M, Gospe Sidney M, Chen John J

This case highlights NMOSD causing junctional vision loss, where plasma exchange, not steroids, effectively restored vision, emphasizing specific treatment for this autoimmune condition.

Gospe Sidney M, Chen John J, Bhatti M Tariq

This review highlights that NMOSD and MOGAD cause distinct, severe forms of optic neuritis. Early diagnosis is crucial for timely treatment to prevent vision loss, with new evidence guiding long-term management.

Padungkiatsagul Tanyatuth, Chen John J, Jindahra Panitha, Akaishi Tetsuya, Takahashi Toshiyuki, Nakashima Ichiro et al.

This study found White patients with MOG-ON had more recurrent disease and extra-optic nerve issues than Asian patients, though visual outcomes were similar for both groups.

Bhatti M Tariq, Mansukhani Sasha A, Chen John J

Liu Katy C, Bhatti M Tariq, Chen John J, Fairbanks Aaron M, Foroozan Rod, McClelland Collin M et al.

This study found papilledema in CVST can be delayed or worsen, often leading to visual field defects. Serial ophthalmic exams are crucial for timely detection and management.

Cohen Devon A, Bhatti M Tariq, Pulido Jose S, Lennon Vanda A, Dubey Divyanshu, Flanagan Eoin P et al.

CRMP5 IgG-positive patients often present with optic disc edema, retinitis, or uveitis, commonly preceding cancer. Testing for CRMP5 IgG is crucial for timely treatment and cancer screening to preserve vision.

Liu Katy C, Fleischman David, Lee Andrew G, Killer Hanspeter E, Chen John J, Bhatti M Tariq

CSF dynamics and the translaminar pressure gradient are key to optic disk health. Alterations in this gradient, driven by ICP and IOP, cause disk edema or cupping, impacting conditions like glaucoma and papilledema.

Chen John J, Pittock Sean J, Flanagan Eoin P, Lennon Vanda A, Bhatti M Tariq

New biomarkers (AQP4-IgG, MOG-IgG) differentiate optic neuritis causes beyond MS, enabling specific treatment and prognostication. Ophthalmologists must test for these in atypical cases.

Chen John J, Tobin W Oliver, Majed Masoud, Jitprapaikulsan Jiraporn, Fryer James P, Leavitt Jacqueline A et al.

This study found AQP4-IgG was absent and MOG-IgG rare (1.7%) in ONTT patients, suggesting these antibodies are uncommon in typical isolated optic neuritis and MOG-ON is distinct from MS.

Roddy Gavin W, Brodsky Michael C, Chen John J