Flammer J

Gugleta K, Waldmann N, Polunina A, Kochkorov A, Katamay R, Flammer J et al.

Glaucoma patients showed reduced retinal vessel dilation to flicker light, indicating systemic neurovascular dysregulation, but this didn't correlate with glaucoma severity, suggesting it's an early, widespread phenomenon.

Gugleta K, Kochkorov A, Waldmann N, Polunina A, Katamay R, Flammer J et al.

This study found glaucoma patients had reduced and delayed retinal vessel dilation to flicker light, indicating impaired vascular regulation potentially contributing to disease progression.

Killer H E, Flammer J, Miller N R

Mozaffarieh M, Grieshaber M C, Orgül S, Flammer J

This review highlights oxidative stress as a glaucoma driver and suggests natural antioxidants (e.g., ginkgo, polyphenols) may offer therapeutic benefits by reducing damage and improving blood flow.

Mansouri K, Orguel S, Mermoud A, Haefliger I, Flammer J, Ravinet E et al.

This study compared diurnal IOP control in glaucoma patients on latanoprost versus surgery. Latanoprost showed similar diurnal variation but greater IOP elevation after a water-drinking test, suggesting different pressure control mechanisms.

Kaeser P, Orgül S, Zawinka C, Reinhard G, Flammer J

This study found choroidal blood flow passively decreases when healthy individuals lie down, mirroring changes in ocular perfusion pressure. This suggests choroidal circulation lacks autoregulation, impacting ocular health.

Vysniauskiene I, Shaarawy T, Flammer J, Haefliger I O

Trabeculectomy significantly lowered contralateral eye IOP for at least one month, suggesting a systemic effect or shared regulatory pathway impacting IOP in both eyes.

Emre M, Orgül S, Haufschild T, Shaw S G, Flammer J

Progressive open-angle glaucoma patients, despite controlled eye pressure, showed significantly higher plasma endothelin-1 levels than stable patients, suggesting ET-1 may contribute to disease progression.

Shaarawy T, Flammer J, Haefliger I O

This review compared pros and cons of glaucoma eye drops versus filtering surgery for reducing intraocular pressure, highlighting their respective roles after the decision to lower IOP is made.

Shaarawy T, Wu R, Mermoud A, Flammer J, Haefliger I O

Non-penetrating glaucoma surgery significantly increased outflow in porcine eyes, but flap suturing reduced this effect. This highlights how surgical technique impacts outflow and intraocular pressure control.

Shaarawy T, Flammer J, Smits G, Mermoud A

This study found that a very low intraocular pressure (≤5 mmHg) on the first day after deep sclerectomy predicts better long-term surgical success, requiring fewer re-interventions.

Emre M, Orgül S, Gugleta K, Flammer J

This study found glaucoma patients with lower ocular blood flow exhibited more systemic vasospasm, suggesting a link between ocular blood flow changes and systemic vascular dysregulation.

Killer H E, Mironov A, Flammer J

Meyer P, Pache M, Loeffler K U, Brydon L, Jockers R, Flammer J et al.

Melatonin MT1 receptors were found in human retinal photoreceptors, ganglion cells, and blood vessels. This suggests melatonin may have diverse roles in ocular health and disease.

Gherghel D, Orgül S, Gugleta K, Flammer J

Glaucoma patients with severe nocturnal blood pressure drops showed altered retrobulbar blood flow, suggesting systemic vascular dysregulation impacts ocular circulation.

Killer H E, Flammer J, Wicki B, Laeng R H

A patient with MS developed acute asymmetric visual field loss due to a chiasmal colloid cyst, highlighting that new visual defects aren't always MS-related and require thorough investigation.

Opial D, Boehnke M, Tadesse S, Lietz-Partzsch A, Flammer J, Munier F et al.

This study found common LHON mutations are rare in unselected normal-tension glaucoma patients, suggesting routine screening is unnecessary unless atypical features or a family history are present.

Schmidt K G, Pillunat L E, Kohler K, Flammer J

This study found ocular pulse amplitude, reflecting choroidal perfusion, is significantly reduced in advanced stages of retinitis pigmentosa, indicating choroidal circulation is affected in later disease.

Lübeck P, Orgül S, Gugleta K, Gherghel D, Gekkieva M, Flammer J

This study found timolol did not significantly alter anterior optic nerve blood flow in nonprogressive glaucoma patients, suggesting its IOP-lowering effect doesn't compromise ocular perfusion in this group.

Beano F, Orgül S, Stümpfig D, Gugleta K, Flammer J

Unoprostone isopropyl 0.15% did not alter ocular blood flow in vasospastic normal-tension glaucoma patients. This suggests it's hemodynamically safe for treating this vulnerable patient group.

Gherghel D, Orgül S, Gugleta K, Gekkieva M, Flammer J

This study found progressive glaucoma patients show a strong link between ocular perfusion pressure and retrobulbar blood flow, suggesting impaired blood flow regulation contributes to disease progression.

Schumann J, Orgül S, Gugleta K, Dubler B, Flammer J

This study found that differences in glaucoma progression between eyes correlate with differences in retrobulbar blood flow, suggesting hemodynamics play a role in progression independent of eye pressure.

Haefliger I O, Fleischhauer J C, Flammer J

This paper suggests caution for glaucoma neuroprotection, noting that promising preclinical results in other neurodegenerative diseases often fail in human trials.

Erb C, Batra A, Lietz A, Bayer A U, Flammer J, Thiel H J

NTG patients exhibited more psychosomatic complaints and emotional instability, suggesting psychological support may benefit those with these disturbances, though cause/effect is unclear.

Flammer J, Haefliger I O, Orgül S, Resink T

Vascular dysregulation, particularly vasospasm and endothelial dysfunction, is a key glaucoma risk factor, making eyes vulnerable to IOP fluctuations and reduced blood flow, leading to optic nerve damage.