Gugleta K

Gugleta K, Waldmann N, Polunina A, Kochkorov A, Katamay R, Flammer J et al.

Glaucoma patients showed reduced retinal vessel dilation to flicker light, indicating systemic neurovascular dysregulation, but this didn't correlate with glaucoma severity, suggesting it's an early, widespread phenomenon.

Gugleta K, Kochkorov A, Waldmann N, Polunina A, Katamay R, Flammer J et al.

This study found glaucoma patients had reduced and delayed retinal vessel dilation to flicker light, indicating impaired vascular regulation potentially contributing to disease progression.

Emre M, Orgül S, Gugleta K, Flammer J

This study found glaucoma patients with lower ocular blood flow exhibited more systemic vasospasm, suggesting a link between ocular blood flow changes and systemic vascular dysregulation.

Gherghel D, Orgül S, Gugleta K, Flammer J

Glaucoma patients with severe nocturnal blood pressure drops showed altered retrobulbar blood flow, suggesting systemic vascular dysregulation impacts ocular circulation.

Lübeck P, Orgül S, Gugleta K, Gherghel D, Gekkieva M, Flammer J

This study found timolol did not significantly alter anterior optic nerve blood flow in nonprogressive glaucoma patients, suggesting its IOP-lowering effect doesn't compromise ocular perfusion in this group.

Beano F, Orgül S, Stümpfig D, Gugleta K, Flammer J

Unoprostone isopropyl 0.15% did not alter ocular blood flow in vasospastic normal-tension glaucoma patients. This suggests it's hemodynamically safe for treating this vulnerable patient group.

Gherghel D, Orgül S, Gugleta K, Gekkieva M, Flammer J

This study found progressive glaucoma patients show a strong link between ocular perfusion pressure and retrobulbar blood flow, suggesting impaired blood flow regulation contributes to disease progression.

Schumann J, Orgül S, Gugleta K, Dubler B, Flammer J

This study found that differences in glaucoma progression between eyes correlate with differences in retrobulbar blood flow, suggesting hemodynamics play a role in progression independent of eye pressure.

Orgül S, Gugleta K, Flammer J

Optic nerve head blood flow is autoregulated by metabolic, myogenic, and endothelial factors. Dysregulation, particularly of nitric oxide and endothelin-1, may contribute to glaucomatous neuropathy, suggesting new therapeutic targets.