Orgül S

Mozaffarieh M, Grieshaber M C, Orgül S, Flammer J

This review highlights oxidative stress as a glaucoma driver and suggests natural antioxidants (e.g., ginkgo, polyphenols) may offer therapeutic benefits by reducing damage and improving blood flow.

Orgül S

Kaeser P, Orgül S, Zawinka C, Reinhard G, Flammer J

This study found choroidal blood flow passively decreases when healthy individuals lie down, mirroring changes in ocular perfusion pressure. This suggests choroidal circulation lacks autoregulation, impacting ocular health.

Emre M, Orgül S, Haufschild T, Shaw S G, Flammer J

Progressive open-angle glaucoma patients, despite controlled eye pressure, showed significantly higher plasma endothelin-1 levels than stable patients, suggesting ET-1 may contribute to disease progression.

Emre M, Orgül S, Gugleta K, Flammer J

This study found glaucoma patients with lower ocular blood flow exhibited more systemic vasospasm, suggesting a link between ocular blood flow changes and systemic vascular dysregulation.

Gherghel D, Orgül S, Gugleta K, Flammer J

Glaucoma patients with severe nocturnal blood pressure drops showed altered retrobulbar blood flow, suggesting systemic vascular dysregulation impacts ocular circulation.

Lübeck P, Orgül S, Gugleta K, Gherghel D, Gekkieva M, Flammer J

This study found timolol did not significantly alter anterior optic nerve blood flow in nonprogressive glaucoma patients, suggesting its IOP-lowering effect doesn't compromise ocular perfusion in this group.

Beano F, Orgül S, Stümpfig D, Gugleta K, Flammer J

Unoprostone isopropyl 0.15% did not alter ocular blood flow in vasospastic normal-tension glaucoma patients. This suggests it's hemodynamically safe for treating this vulnerable patient group.

Gherghel D, Orgül S, Gugleta K, Gekkieva M, Flammer J

This study found progressive glaucoma patients show a strong link between ocular perfusion pressure and retrobulbar blood flow, suggesting impaired blood flow regulation contributes to disease progression.

Schumann J, Orgül S, Gugleta K, Dubler B, Flammer J

This study found that differences in glaucoma progression between eyes correlate with differences in retrobulbar blood flow, suggesting hemodynamics play a role in progression independent of eye pressure.

Flammer J, Haefliger I O, Orgül S, Resink T

Vascular dysregulation, particularly vasospasm and endothelial dysfunction, is a key glaucoma risk factor, making eyes vulnerable to IOP fluctuations and reduced blood flow, leading to optic nerve damage.

Orgül S, Gugleta K, Flammer J

Optic nerve head blood flow is autoregulated by metabolic, myogenic, and endothelial factors. Dysregulation, particularly of nitric oxide and endothelin-1, may contribute to glaucomatous neuropathy, suggesting new therapeutic targets.

Saruhan A, Orgül S, Koçak I, Prünte C, Flammer J

HRT optic nerve parameters in normal eyes showed optic cup shape provides independent topographic information, potentially improving glaucoma diagnosis beyond standard measures.

Bohdanecka Z, Orgül S, Prünte C, Flammer J

This study found that Heidelberg Retina Flowmeter scan area significantly impacts optic disc "Flow" measurements, with window location affecting long-term variability, crucial for reliable glaucoma monitoring.

Prünte C, Orgül S, Flammer J

This review highlights that beyond IOP, vascular dysregulation and impaired ocular blood flow are major, systemic risk factors in glaucoma, crucial for understanding disease progression.

Orgül S, Prünte C, Flammer J

This abstract explores how endothelium-derived substances might contribute to normal-tension glaucoma via vascular dysregulation, suggesting potential new vasodilator therapies, though clinical relevance needs further study.

Flammer J, Orgül S

Glaucoma involves optic nerve blood flow changes, likely due to vascular dysregulation (vasospasm/hypotension) rather than arteriosclerosis, highlighting its role beyond just eye pressure.

Orgül S, Cioffi G A, Bacon D R, Van Buskirk E M

Chronic endothelin-1 delivery to primate optic nerves significantly reduced blood flow, creating a novel model for studying hemodynamic contributions to optic neuropathies like glaucoma.

Orgül S, Mansberger S, Bacon D R, Van Buskirk E M, Cioffi G A

Topical beta-blockers (timolol, betaxolol) in rabbits showed no observable optic nerve blood vessel constriction. This suggests these glaucoma medications don't directly impair optic nerve blood flow, which is clinically relevant for patient management.

Orgül S, Flammer J

Brief, moderate exertion (e.g., knee bends) rapidly lowers IOP, likely via sympathetic activity. This suggests even short physical activity can acutely impact eye pressure.