Gong Bo

Yang Jialiang, Yang Fang, Li Kecheng, Gu Junming, Cheng Yilian, Luo Qian et al.

Increased erythrocyte osmotic fragility is a novel glaucoma risk factor. Integrating EOF with other blood biomarkers achieved high predictive accuracy (88.68%), enhancing diagnosis, especially for normal tension glaucoma, by identifying red blood cell susceptibility.

Lu Shi Yao, He Zong Ze, Xu Jia Xin, Yang Chen, Chen Li Jia, Gong Bo

This meta-analysis confirmed genetic variants (rs10483727, rs33912345) in the SIX1-SIX6 locus are linked to primary open-angle glaucoma, particularly in East Asian and Caucasian populations, highlighting ethnic differences in disease risk.

Luo Huaichao, Chen Yuhong, Ye Zimeng, Sun Xinghuai, Shi Yi, Luo Qian et al.

This study found specific ABCA1 gene haplotypes, not individual variants, were associated with increased or decreased primary angle closure glaucoma risk in Han Chinese, suggesting different genetic bases from POAG.

Shuai Ping, Yu Man, Li Xiulan, Zhou Yu, Liu Xiaoqi, Liu Yuping et al.

This meta-analysis confirmed genetic links between PLEKHA7 and COL11A1 SNPs and primary angle closure glaucoma, especially in Asian populations, suggesting potential for risk stratification.

Gong Bo, Qu Chao, Li Xiulan, Shi Yi, Lin Ying, Zhou Yu et al.

This study found novel and known CYP1B1 mutations in a subset of Chinese primary open-angle glaucoma patients, suggesting its involvement in disease development and improving pathogenic understanding.

Jia Li-Yun, Gong Bo, Pang Chi-Pui, Huang Yao, Lam Dennis Shun-Chiu, Wang Ningli et al.

This study found a novel myocilin mutation causing juvenile glaucoma. A natural osmolyte, TMAO, improved the mutant protein's folding, secretion, and reduced cell stress. This suggests a potential chaperone-based therapy for myocilin-related glaucoma.