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Groth Sylvia L

🇴🇲 Vanderbilt Health
ORCIDOpenAlex14 articles in GJC

14 articles in GJC

4.

Phase 1b Randomized Controlled Study of Short Course Topical Recombinant Human Nerve Growth Factor (rhNGF) for Neuroenhancement in Glaucoma: Safety, Tolerability, and Efficacy Measure Outcomes.

Beykin Gala, Stell Laurel, Halim Muhammad Sohail, Nuñez Mariana, Popova Lilia, Nguyen Bac T et al.

Am J OphthalmolNov 202131 citationsRandomized Controlled Trial

This study found topical rhNGF eye drops for glaucoma were safe and well-tolerated. While no significant short-term neuroenhancement was detected, trends suggest further neuroprotection trials are warranted.

5.

Racial/Ethnic Disparities in Ophthalmology Clinical Trials Resulting in US Food and Drug Administration Drug Approvals From 2000 to 2020.

Berkowitz Sean T, Groth Sylvia L, Gangaputra Sapna, Patel Shriji

JAMA OphthalmolJun 202154 citationsCohort Study

This study found Black, Hispanic/Latinx, and other non-White participants were underrepresented in FDA-approved ophthalmology drug trials. Despite some improvement, further efforts are needed to ensure diverse enrollment for valid, equitable results.

13.

Paintball trauma and mechanisms of optic nerve injury: rotational avulsion and rebound evulsion.

Sponsel William E, Gray Walt, Groth Sylvia L, Stern Amber R, Walker James D

Invest Ophthalmol Vis SciDec 20116 citationsBasic Science

Paintball trauma mechanisms were studied using porcine eyes and supercomputer models. Key finding: Two distinct optic nerve injury mechanisms (rotational avulsion vs. rebound evulsion) depend on impact trajectory, with implications for understanding blunt ocular trauma.

14.

Numerical modeling of paintball impact ocular trauma: identification of progressive injury mechanisms.

Gray Walt, Sponsel William E, Scribbick Frank W, Stern Amber R, Weiss Carl E, Groth Sylvia L et al.

Invest Ophthalmol Vis SciSep 201123 citationsBasic Science

Computer modeling of paintball eye impacts revealed specific mechanisms like ciliary body strain and pressure waves cause injuries like angle recession, lens displacement, and retinal damage, explaining blunt ocular trauma.

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