Loewen Nils

Oltmann Jannis, Morell Mark, Dakroub Mohamad, Verma-Fuehring Raoul, Hillenkamp Jost, Loewen Nils

VEGF-A dilated distal outflow tract vessels and increased outflow facility, even without trabecular meshwork. This suggests a novel, independent mechanism for regulating intraocular pressure relevant to glaucoma.

Groth Sylvia L, Albeiruti Eiyass, Nunez Mariana, Fajardo Roman, Sharpsten Lucie, Loewen Nils et al.

Short-term NSAID or steroid drops after SLT significantly improved IOP reduction at 12 weeks. This suggests anti-inflammatory treatment can enhance SLT efficacy.

Esfandiari Hamed, Loewen Nils

Akil Handan, Chopra Vikas, Huang Alex, Loewen Nils, Noguchi Jonathan, Francis Brian A

Trabectome surgery showed similar positive outcomes for both pigmentary and primary open-angle glaucoma patients, indicating its effectiveness across these glaucoma types.

Zhang Xinbo, Loewen Nils, Tan Ou, Greenfield David S, Schuman Joel S, Varma Rohit et al.

OCT measurements, particularly ganglion cell complex (GCC) and nerve fiber layer (NFL) thickness, predict future glaucomatous visual field loss, aiding early identification of at-risk patients.

Le Phuc V, Zhang Xinbo, Francis Brian A, Varma Rohit, Greenfield David S, Schuman Joel S et al.

This study found advanced glaucoma imaging technologies show minimal site-to-site variation compared to glaucoma changes, supporting data pooling across centers for better research.

Fautsch Michael P, Bahler Cindy K, Vrabel Anne M, Howell Kyle G, Loewen Nils, Teo Wulin L et al.

Human myocilin, when combined with aqueous humor, significantly increased outflow resistance in human eye models, suggesting its role in glaucoma development by impeding fluid drainage.

Loewen Nils, Fautsch Michael P, Teo Wu-Lin, Bahler Cindy K, Johnson Douglas H, Poeschla Eric M

Researchers achieved long-term, targeted gene expression in the eye's outflow tract using a single lentiviral injection in cats. This enables better glaucoma research models and future gene therapies.

Loewen Nils, Bahler Cindy, Teo Wu-Lin, Whitwam Todd, Peretz Mary, Xu Ruifang et al.

FIV gene therapy vectors in human eye anterior segments showed high gene expression in the trabecular meshwork with only transient, small outflow facility changes, suggesting suitability for glaucoma gene therapy.