He Weixiong

Marzban Maryam, Diaz Torres Santiago, Yu Regina, He Weixiong, Mackey David A, Segrè Ayellet V et al.

This study found polygenic risk scores (PRSs) significantly predict Normal-Tension Glaucoma (NTG) risk, suggesting PRSs could aid early detection and personalized assessment for this challenging condition.

Le Ngoc-Quynh, He Weixiong, Law Matthew H, Medland Sarah E, Mackey David A, Hewitt Alex W et al.

This study found a rare glaucoma gene variant (MYOC p.Gln368Ter) can be accurately genotyped from array data. Integrating it with polygenic risk scores significantly improves risk stratification for carriers, aiding early diagnosis.

Kolovos Antonia, Qassim Ayub, Hassall Mark M, Marshall Henry N, Schmidt Joshua, Nguyen Thi Thi et al.

Polygenic risk scores for glaucoma, IOP, and VCDR stratify glaucoma risk and severity in pseudoexfoliation patients, identifying those prone to earlier diagnosis and worse outcomes, aiding personalized management.

He Weixiong, Lee Samantha Sze-Yee, Diaz Torres Santiago, Han Xikun, Gharahkhani Puya, Hunter Michael et al.

Polygenic risk scores for VCDR and IOP predict glaucoma risk factors, suggesting their clinical utility for early detection, personalized IOP management, and identifying risk beyond normal IOP.

He Weixiong, Han Xikun, Ong Jue-Sheng, Wu Yeda, Hewitt Alex W, Mackey David A et al.

Researchers identified new genetic risk factors for age-related macular degeneration (AMD) and developed an improved polygenic risk score, enhancing AMD risk prediction for diverse populations.

Marshall Henry N, Mullany Sean, Han Xikun, Qassim Ayub, He Weixiong, Hassall Mark M et al.

High polygenic risk for glaucoma predicts earlier initiation and escalation of IOP-lowering treatment, suggesting genetic testing could guide personalized management strategies.

Siggs Owen M, Qassim Ayub, Han Xikun, Marshall Henry N, Mullany Sean, He Weixiong et al.

High polygenic risk in early POAG was linked to faster visual field worsening despite treatment, suggesting PRS could identify patients needing more intensive monitoring and care.

He Weixiong, Han Xikun, Ong Jue-Sheng, Hewitt Alex W, Mackey David A, Gharahkhani Puya et al.

This study linked corneal resistance and thickness genetic markers to keratoconus risk. Identifying new genetic loci improves early prediction models, aiding timely intervention for this corneal disease.