Hewitt Alex W

Lee Samantha Sze-Yee, Diaz Torres Santiago, Lingham Gareth, Yazar Seyhan, Hunter Michael, Craig Jamie E et al.

Glaucoma polygenic scores linked to optic nerve measures from young adulthood, with stronger effects in older adults, suggesting genetic impact on the optic nerve manifests later in life.

Lee Samantha Sze-Yee, Lingham Gareth, Hewitt Alex W, Mackey David A

This study found healthy young adults (20-28) experience normal age-related decreases in retinal nerve fiber layer thickness and intraocular pressure, and increased central corneal thickness. This helps clinicians distinguish normal aging from disease.

Le Ngoc-Quynh, He Weixiong, Law Matthew H, Medland Sarah E, Mackey David A, Hewitt Alex W et al.

This study found a rare glaucoma gene variant (MYOC p.Gln368Ter) can be accurately genotyped from array data. Integrating it with polygenic risk scores significantly improves risk stratification for carriers, aiding early diagnosis.

He Weixiong, Lee Samantha Sze-Yee, Diaz Torres Santiago, Han Xikun, Gharahkhani Puya, Hunter Michael et al.

Polygenic risk scores for VCDR and IOP predict glaucoma risk factors, suggesting their clinical utility for early detection, personalized IOP management, and identifying risk beyond normal IOP.

Chaurasia Abadh K, Liu Guei-Sheung, Greatbatch Connor J, Gharahkhani Puya, Craig Jamie E, Mackey David A et al.

A deep learning model effectively screened for glaucoma using fundus images, achieving high accuracy (AUROC 0.9920). This model shows promise for population-level screening, despite needing further validation on diverse datasets.

Chaurasia Abadh K, MacGregor Stuart, Craig Jamie E, Mackey David A, Hewitt Alex W

Researchers used synthetic and real optic disc images to train deep learning models for glaucoma detection. Combining synthetic and real data improved model performance and generalization, offering a strategy to optimize AI for clinical glaucoma diagnosis.

Chaurasia Abadh K, Greatbatch Connor J, Han Xikun, Gharahkhani Puya, Mackey David A, MacGregor Stuart et al.

A deep learning model accurately and precisely quantified cup-to-disc ratio from fundus images. This highly accurate automated method can improve glaucoma screening efficiency and consistency.

Saks Danit G, Schulz Angela, Qassim Ayub, Marshall Henry, Hewitt Alex W, MacGregor Stuart et al.

Higher genetic glaucoma risk correlates with retinal vascular and nerve fiber defects, suggesting a localized vascular pathophysiology relevant for early glaucoma detection and high-risk individuals.

He Weixiong, Han Xikun, Ong Jue-Sheng, Wu Yeda, Hewitt Alex W, Mackey David A et al.

Researchers identified new genetic risk factors for age-related macular degeneration (AMD) and developed an improved polygenic risk score, enhancing AMD risk prediction for diverse populations.

Liu Qinqin, Davis John, Han Xikun, Mackey David A, MacGregor Stuart, Craig Jamie E et al.

This study found polygenic risk score screening for primary open-angle glaucoma is a promising, cost-effective strategy in the UK and Australia, potentially avoiding blindness.

Hollitt Georgina L, Siggs Owen M, Ridge Bronwyn, Keane Miriam C, Mackey David A, MacGregor Stuart et al.

This study found strong interest (71.3%) in glaucoma genetic risk assessment among unaffected individuals, particularly those concerned about the disease or proactive about eye health. This supports integrating polygenic risk scores into clinical practice.

Dyer Kathleen I C, Sanfilippo Paul G, Yazar Seyhan, Craig Jamie E, Hewitt Alex W, Newnham John P et al.

This study found consistently large fetal head circumference during gestation is linked to thicker adult retinal nerve fiber layer, suggesting fetal development impacts long-term optic nerve health.

He Weixiong, Han Xikun, Ong Jue-Sheng, Hewitt Alex W, Mackey David A, Gharahkhani Puya et al.

This study linked corneal resistance and thickness genetic markers to keratoconus risk. Identifying new genetic loci improves early prediction models, aiding timely intervention for this corneal disease.

Chaurasia Abadh K, Greatbatch Connor J, Hewitt Alex W

This meta-analysis found AI demonstrates high accuracy for glaucoma diagnosis from imaging, but inconsistent performance with mixed datasets and external validation means standardization is crucial for clinical implementation.

Lee Samantha Sze-Yee, McVeigh Joanne, Straker Leon, Howie Erin K, Yazar Seyhan, Haynes Andrew et al.

This study found higher cardiovascular fitness in adolescence correlated with thicker retinal nerve fiber layers in young adults, suggesting a link between heart health and neuroretinal integrity, potentially impacting future glaucoma risk.

Siggs Owen M, Han Xikun, Qassim Ayub, Souzeau Emmanuelle, Kuruvilla Shilpa, Marshall Henry N et al.

This study compared monogenic and polygenic glaucoma risks, finding high polygenic risk is as significant as single-gene mutations, more common, and associated with similar diagnosis age, making it clinically important for risk stratification.

Han Xikun, Hewitt Alex W, MacGregor Stuart

This review explored genetic risk profiling for glaucoma, finding polygenic risk scores show promise in identifying high-risk individuals. This could enable earlier intervention, improving patient outcomes.

Lee Samantha Sze-Yee, Sanfilippo Paul G, Yazar Seyhan, Pennell Craig E, Hewitt Alex W, Wang Carol A et al.

This study found weak associations between some stress markers (ACTH, adrenal sensitivity) and thinner RNFL in young adults, suggesting limited clinical evidence that stress directly impacts retinal nerve health.

Han Xikun, Ong Jue-Sheng, An Jiyuan, Craig Jamie E, Gharahkhani Puya, Hewitt Alex W et al.

Genetic analysis showed myopia and higher intraocular pressure both increase retinal detachment risk. This suggests myopia prevention could help reduce retinal detachment incidence.

Lee Samantha S Y, Lingham Gareth, Alonso-Caneiro David, Chen Fred K, Yazar Seyhan, Hewitt Alex W et al.

This study found young adults' average central choroidal thickness was 370µm. Thinner choroids (<300µm) were linked to worse visual acuity, suggesting choroidal thickness may predict visual function.

Hogarty Daniel T, Hogarty Joseph P, Hewitt Alex W

Smartphones offer diverse ophthalmic apps, from visual acuity to imaging. However, their widespread use lacks clear evidence regarding validation, regulation, and data security, necessitating caution in clinical practice.

Lee Samantha S Y, McArdle Nigel, Sanfilippo Paul G, Yazar Seyhan, Eastwood Peter R, Hewitt Alex W et al.

This study found obstructive sleep apnea in young adults is linked to thinner peripapillary retinal nerve fiber layer, suggesting early glaucoma risk.

Lee Samantha S Y, Yazar Seyhan, Pasquale Louis R, Sanfilippo Paul G, Hewitt Alex W, Hickey Martha et al.

This study found young women who had given birth had larger optic disc rim widths, suggesting a potential link between parity and optic nerve health, which warrants further investigation for glaucoma risk.

Mackey David A, Craig Jamie E, Hewitt Alex W

Singh Larry N, Crowston Jonathan G, Lopez Sanchez M Isabel G, Van Bergen Nicole J, Kearns Lisa S, Hewitt Alex W et al.

This study found specific mitochondrial DNA variations (haplogroup U, MT-ND2 variants) may protect European individuals from primary open-angle glaucoma, suggesting potential biomarkers for risk and therapy.