Van Bergen Nicole J

Singh Larry N, Crowston Jonathan G, Lopez Sanchez M Isabel G, Van Bergen Nicole J, Kearns Lisa S, Hewitt Alex W et al.

This study found specific mitochondrial DNA variations (haplogroup U, MT-ND2 variants) may protect European individuals from primary open-angle glaucoma, suggesting potential biomarkers for risk and therapy.

Lee Shanjean, Sheck Leo, Crowston Jonathan G, Van Bergen Nicole J, O'Neill Evelyn C, O'Hare Fleur et al.

POAG patient lymphoblasts showed impaired mitochondrial complex-I function, reducing ATP synthesis and respiration. This suggests systemic bioenergetic defects that could increase retinal ganglion cell vulnerability in glaucoma.

Van Bergen Nicole J, Wood John P M, Chidlow Glyn, Trounce Ian A, Casson Robert J, Ju Won-Kyu et al.

RGC-5 cells, widely used in glaucoma research, were recharacterized and found to be mouse, not rat, and lack true retinal ganglion cell markers, urging caution in their use as RGC models.

Kong George Y X, Van Bergen Nicole J, Trounce Ian A, Crowston Jonathan G

This review suggests age-related mitochondrial dysfunction in retinal ganglion cells contributes to glaucoma by reducing energy and promoting cell death, offering new therapeutic targets.