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4 articles in GJC
Kastner Alan, Stuart Kelsey V, Montesano Giovanni, De Moraes C Gustavo, Kang Jae H, Wiggs Janey L et al.
This study found calcium channel blocker use linked to 39% higher glaucoma odds and thinner retinal nerve layers, suggesting an IOP-independent neurodegenerative mechanism.
Pasquale Louis R, Khawaja Anthony P, Wiggs Janey L, Kim Jihye, Hysi Pirro, Elze Tobias et al.
This study linked specific metabolites to eye health: branched-chain amino acids with lower IOP, HDL metabolites with thinner RNFL, and LDL metabolites with thicker GCIPL, identifying potential biomarkers for glaucoma risk.
Hamid Sana, Desai Parul, Hysi Pirro, Burr Jennifer M, Khawaja Anthony P
UK NSC found glaucoma screening isn't recommended due to lack of accurate tests and improved outcomes. Opportunistic case finding remains key, with future targeted screening and new tech offering potential.
Xu Zihe, Hysi Pirro, Khawaja Anthony P
Genetic studies identified over 100 common variants influencing IOP, predicting glaucoma risk (76% accuracy for high-pressure type) and revealing new therapeutic targets like lymphangiogenesis and lipid metabolism.
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