Kardon Randy H

Woods Brian, Szanto David, Wang Jui-Kai, Erekat Asala, Stern Lola, Golden Aaron et al.

Acetazolamide significantly reduces retinal venule diameter and V:A ratio in IIH papilledema, correlating with Frisén grade and CSF pressure. This non-invasive, deep learning-based method offers a promising biomarker for monitoring treatment efficacy.

Szanto David, Wang Jui-Kai, Woods Brian, Garvin Mona K, Johnson Brett A, Kardon Randy H et al.

Deep learning with 3D OCT accurately differentiated papilledema, NAION, and healthy eyes. This offers a robust, automated diagnostic tool to distinguish causes of optic disc swelling, aiding clinical decision-making.

Linton Edward F, Ahmad Noor-Us-Sabah, Filister Riley, Wang Jui-Kai, Sohn Elliott H, Kardon Randy H

LSFG revealed significantly reduced choroidal and inner retinal blood flow in non-exudative AMD patients, independent of perfusion pressure. This widespread reduction suggests blood flow compromise is a key risk factor and driver of dry AMD progression.

Elwood Benjamin W, Godwin Cheyanne R, Anders Jeffrey J, Kardon Randy H, Gramlich Oliver W

In an MS mouse model, visual biomarkers (pERG, OCT) objectively correlated with motor deficits and optic nerve damage, offering translatable outcomes for testing new MS therapies.

Wang Jui-Kai Ray, Linton Edward F, Johnson Brett A, Kupersmith Mark J, Garvin Mona K, Kardon Randy H

A deep learning model (biVAE) quantified diverse papilledema structural patterns from OCT scans using only two variables. This offers a novel way to visualize and track papilledema changes during treatment.

Tamplin Michelle R, Deng Wenxiang, Garvin Mona K, Binkley Elaine M, Hyer Daniel E, Buatti John M et al.

Brachytherapy for uveal melanoma causes early microvascular damage and visual field loss, preceding inner retinal thinning. This suggests radiation-induced ischemia is a primary early event in radiation retinopathy.

Gramlich Oliver W, Brown Alexander J, Godwin Cheyanne R, Chimenti Michael S, Boland Lauren K, Ankrum James A et al.

Systemic mesenchymal stem cells mitigated RGC damage and improved visual function in MS mice, potentially via cholesterol and HIF-1 pathways, offering new therapeutic targets for MS-related vision loss.

Harper Matthew M, Hedberg-Buenz Adam, Herlein Judith, Abrahamson Eric E, Anderson Michael G, Kuehn Markus H et al.

Blast TBI in AD-prone mice worsened retinal/optic nerve damage and modestly increased brain amyloid. This suggests AD genetic risk amplifies retinal vulnerability to blast injury.

Wall Michael, Subramani Ashwin, Chong Luke X, Galindo Ramon, Turpin Andrew, Kardon Randy H et al.

This study found IIH patients have significant peripheral visual field loss, often a temporal wedge, exceeding central loss. Full visual field testing is clinically useful for IIH.

Wang Jui-Kai, Kardon Randy H, Ledolter Johannes, Sibony Patrick A, Kupersmith Mark J, Garvin Mona K

Acetazolamide and weight loss in IIH reduced pRPE/BM deformation away from the vitreous, reflecting decreased pressure differential. Weight loss alone improved optic disc swelling via a different mechanism.

Yeh Connie Y, Koehl Kristin L, Harman Christine D, Iwabe Simone, Guzman José M, Petersen-Jones Simon M et al.

This study found chromatic pupillometry effectively differentiates rod, cone, and ipRGC function in dogs. This offers a valuable tool for diagnosing canine retinal and optic nerve diseases.

Mallery Robert M, Poolman Pieter, Thurtell Matthew J, Wang Jui-Kai, Garvin Mona K, Ledolter Johannes et al.

OCT-derived fixation instability and eccentricity are increased in optic neuropathy, predicting central vision loss. This method links fixation to preserved retinal ganglion cells, improving structure-function assessment.

Pemp Berthold, Kardon Randy H, Kircher Karl, Pernicka Elisabeth, Schmidt-Erfurth Ursula, Reitner Andreas

Averaging more OCT frames (100 vs. 1 or 16) significantly improves retinal nerve fiber layer thickness measurement reproducibility. This enhances early glaucoma detection and monitoring by reducing measurement variability.

Mohan Kabhilan, Kecova Helga, Hernandez-Merino Elena, Kardon Randy H, Harper Matthew M

Blast injury in mice causes retinal ganglion cell damage, detectable by non-invasive tests, potentially serving as objective biomarkers for traumatic brain injury.

Tang Li, Kardon Randy H, Wang Jui-Kai, Garvin Mona K, Lee Kyungmoo, Abràmoff Michael D

This study found that automated 3D analysis of optic disc volume from stereo fundus photos correlates well with OCT and expert grading, offering a cost-effective papilledema assessment, especially for telemedicine.

Wang Jui-Kai, Kardon Randy H, Kupersmith Mark J, Garvin Mona K

This study developed an automated OCT method to quantify optic disc swelling volume in papilledema. It found volume strongly correlates with Frisén grades, offering a more objective and continuous swelling assessment than current methods.

Zode Gulab S, Bugge Kevin E, Mohan Kabhilan, Grozdanic Sinisa D, Peters Joseph C, Koehn Demelza R et al.

Topical PBA eye drops in a myocilin glaucoma mouse model reduced elevated eye pressure and preserved vision, suggesting a potential novel treatment for myocilin-associated glaucoma by improving protein secretion.

Kupersmith Mark J, Sibony Patrick, Mandel Gary, Durbin Mary, Kardon Randy H

This study found that papilledema, unlike other optic disc swellings, causes inward deflection of the peripapillary RPE/BM, likely due to elevated intracranial pressure, which resolves with treatment.

Harper Matthew M, Grozdanic Sinisa D, Blits Bas, Kuehn Markus H, Zamzow Daniel, Buss Janice E et al.

BDNF-secreting stem cells protected retinal function and optic nerve structure in hypertensive rat eyes, suggesting a potential neuroprotective glaucoma therapy.

Grozdanic Sinisa D, Lazic Tatjana, Kuehn Markus H, Harper Matthew M, Kardon Randy H, Kwon Young H et al.

This rat study found that while CNTF was naturally upregulated after acute high IOP, exogenous BDNF or GDNF, but not CNTF, significantly protected optic nerve function, suggesting their therapeutic potential in glaucoma.

Hood Donald C, Anderson Susan C, Wall Michael, Raza Ali S, Kardon Randy H

This study analyzed glaucoma patients' RNFL and visual field data, finding significant variability from individual differences and factors like epiretinal membranes. This improves understanding of structure-function relationships in glaucoma.

Grozdanic Sinisa D, Kecova Helga, Harper Matthew M, Nilaweera Wijitha, Kuehn Markus H, Kardon Randy H

This canine PACG model showed progressive IOP elevation, angle collapse, and retinal ganglion cell loss, confirming it mimics human PACG and is useful for studying disease mechanisms.

Hood Donald C, Anderson Susan, Rouleau Jacinthe, Wenick Adam S, Grover Larissa K, Behrens Myles M et al.

This study found a linear relationship between retinal nerve fiber loss and visual field sensitivity in ischemic optic neuropathy patients, similar to glaucoma. This model helps estimate residual nerve tissue, potentially identifying viable but dysfunctional axons.

Hood Donald C, Kardon Randy H

This study developed a linear model relating OCT RNFL thickness to SAP sensitivity loss in glaucoma. It found RNFL becomes asymptotic after 10dB loss, and residual RNFL is ~1/3 normal, helping clarify when structural vs. functional damage appears first based on initial RNFL thickness.

Hood Donald C, Anderson Susan C, Wall Michael, Kardon Randy H

This study confirmed a linear relationship between OCT-measured retinal nerve fiber layer thickness and visual field sensitivity loss in glaucoma, providing a framework to assess structural and functional test efficacy.