Wang Jui-Kai

Szanto David, Erekat Asala, Woods Brian, Wang Jui-Kai, Garvin Mona, Johnson Brett et al.

Multimodal deep learning (OCT+fundus) significantly improves diagnostic accuracy (97.5-98.3%) for differentiating papilledema, NAION, and healthy eyes. This enhances optic nerve head swelling diagnosis and management.

Szanto David, Woods Brian, Wang Jui-Kai, Wall Michael, Elze Tobias, Kupersmith Mark

Archetypal analysis revealed distinct visual field loss patterns in NAION, showing global loss increases over time and greater severity in Asian individuals, improving disease characterization and prognosis.

Woods Brian, Szanto David, Wang Jui-Kai, Erekat Asala, Stern Lola, Golden Aaron et al.

Acetazolamide significantly reduces retinal venule diameter and V:A ratio in IIH papilledema, correlating with Frisén grade and CSF pressure. This non-invasive, deep learning-based method offers a promising biomarker for monitoring treatment efficacy.

Szanto David, Wang Jui-Kai, Woods Brian, Erekat Asala, Garvin Mona, Kardon Randy et al.

Deep learning on unsegmented 3D OCT scans accurately distinguished glaucoma, NAION, and optic neuritis from healthy eyes. This automated method offers a promising tool for diagnosing and managing optic neuropathies.

Szanto David, Wang Jui-Kai, Woods Brian, Garvin Mona K, Johnson Brett A, Kardon Randy H et al.

Deep learning with 3D OCT accurately differentiated papilledema, NAION, and healthy eyes. This offers a robust, automated diagnostic tool to distinguish causes of optic disc swelling, aiding clinical decision-making.

Linton Edward F, Ahmad Noor-Us-Sabah, Filister Riley, Wang Jui-Kai, Sohn Elliott H, Kardon Randy H

LSFG revealed significantly reduced choroidal and inner retinal blood flow in non-exudative AMD patients, independent of perfusion pressure. This widespread reduction suggests blood flow compromise is a key risk factor and driver of dry AMD progression.

Szanto David, Wall Michael, Chong Luke X, Woods Brian, Elze Tobias, Wang Jui-Kai et al.

Archetypal analysis revealed similar visual field loss patterns for stimulus sizes III and V in glaucoma and NAION, supporting size V's use for monitoring moderate to severe vision loss.

Banik Rudrani, Kupersmith Mark J, Wang Jui-Kai, Garvin Mona K

Acetazolamide did not lower IOP in IIH patients without glaucoma, despite reducing CSF pressure, suggesting normal eyes compensate and IOP is not directly affected by ACZ in this context.

Wang Jui-Kai, Kardon Randy H, Ledolter Johannes, Sibony Patrick A, Kupersmith Mark J, Garvin Mona K

Acetazolamide and weight loss in IIH reduced pRPE/BM deformation away from the vitreous, reflecting decreased pressure differential. Weight loss alone improved optic disc swelling via a different mechanism.

Kupersmith Mark J, Sibony Patrick A, Feldon Steven E, Wang Jui-Kai, Garvin Mona, Kardon Randy

Acetazolamide treatment for IIH significantly reduced retinal and choroidal folds, but not creases, reflecting biodynamic changes. Persistent folds despite swelling reduction suggest permanent tissue alterations.

Kupersmith Mark J, Garvin Mona K, Wang Jui-Kai, Durbin Mary, Kardon Randy

This study found macular GCL+IPL thinning occurs within 1-2 months in acute NAION, earlier than RNFL thinning. This makes GCL+IPL a better early biomarker for neuronal damage in NAION.

Mallery Robert M, Poolman Pieter, Thurtell Matthew J, Wang Jui-Kai, Garvin Mona K, Ledolter Johannes et al.

OCT-derived fixation instability and eccentricity are increased in optic neuropathy, predicting central vision loss. This method links fixation to preserved retinal ganglion cells, improving structure-function assessment.

Sibony Patrick A, Kupersmith Mark J, Feldon Steven E, Wang Jui-Kai, Garvin Mona

This study found retinal/choroidal folds are common in IIH papilledema, better detected by OCT, and represent biomechanical stress on the optic nerve head, not directly linked to vision loss.

Tang Li, Kardon Randy H, Wang Jui-Kai, Garvin Mona K, Lee Kyungmoo, Abràmoff Michael D

This study found that automated 3D analysis of optic disc volume from stereo fundus photos correlates well with OCT and expert grading, offering a cost-effective papilledema assessment, especially for telemedicine.

Wang Jui-Kai, Kardon Randy H, Kupersmith Mark J, Garvin Mona K

This study developed an automated OCT method to quantify optic disc swelling volume in papilledema. It found volume strongly correlates with Frisén grades, offering a more objective and continuous swelling assessment than current methods.