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The Relationship Between the Renin-Angiotensin-Aldosterone System and NMDA Receptor-Mediated Signal and the Prevention of Retinal Ganglion Cell Death.
Kobayashi Mamoru, Hirooka Kazuyuki, Ono Aoi, Nakano Yuki, Nishiyama Akira, Tsujikawa Akitaka
Invest Ophthalmol Vis SciMar 201712 citationsBasic Science
This study found RAAS and NMDA pathways cause retinal ganglion cell death independently. Spironolactone protected against aldosterone-induced damage, and memantine against NMDA-induced damage, suggesting distinct mechanisms for RGC neuroprotection.