Nishiyama Akira

2 articles in GJC

The Relationship Between the Renin-Angiotensin-Aldosterone System and NMDA Receptor-Mediated Signal and the Prevention of Retinal Ganglion Cell Death.

Kobayashi Mamoru, Hirooka Kazuyuki, Ono Aoi, Nakano Yuki, Nishiyama Akira, Tsujikawa Akitaka

Invest Ophthalmol Vis SciMar 201712 citationsBasic Science

This study found RAAS and NMDA pathways cause retinal ganglion cell death independently. Spironolactone protected against aldosterone-induced damage, and memantine against NMDA-induced damage, suggesting distinct mechanisms for RGC neuroprotection.

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Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels.

Fujita Tomoyoshi, Hirooka Kazuyuki, Nakamura Takehiro, Itano Toshifumi, Nishiyama Akira, Nagai Yukiko et al.

Invest Ophthalmol Vis SciJun 201250 citationsBasic Science

An AT1-R blocker protected retinal neurons in rats by reducing glutamate release and oxidative stress after ischemia, suggesting its potential for glaucoma neuroprotection.

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Nishiyama Akira

The Relationship Between the Renin-Angiotensin-Aldosterone System and NMDA Receptor-Mediated Signal and the Prevention of Retinal Ganglion Cell Death.

Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels.