Lee Helena

Patel Aarti, Purohit Ravi, Lee Helena, Sheth Viral, Maconachie Gail, Papageorgiou Eleni et al.

Handheld SD-OCT successfully imaged pediatric ONH development. Key finding: Disc/cup diameters increase with age, while peripapillary RNFL initially decreases then slowly increases, providing normative data for clinical use.

Lee Helena, Proudlock Frank A, Gottlob Irene

Handheld OCT offers novel insights into pediatric retinal and optic nerve diseases, aiding diagnosis, monitoring, and potentially guiding earlier, more effective treatments for conditions like ROP, nystagmus, and glaucoma.

Mohammad Sarim, Gottlob Irene, Sheth Viral, Pilat Anastasia, Lee Helena, Pollheimer Ellen et al.

Albinism causes distinct optic nerve head maldevelopment, with smaller optic cups, larger rims, and thinner retinal nerve fiber layers, crucial for differentiating from glaucoma.

Pilat Anastasia V, Proudlock Frank A, Kumar Periyasamy, Lee Helena, Papageorgiou Eleni, Gottlob Irene

This study used OCT to find distinct macular layer changes in optic nerve head drusen and optic disc edema, suggesting these specific patterns aid diagnosis and understanding of each condition.

Lee Helena, Proudlock Frank, Gottlob Irene

Handheld OCT reliably measures foveal thickness in young children, even with nystagmus, showing excellent reproducibility. This validates its future use for diagnosing and monitoring pediatric eye diseases.

Lee Helena, Khan Rizwana, O'Keefe Michael

Aniridia, caused by PAX6 mutations, leads to widespread ocular defects and profibrotic complications. While some treatments show promise (e.g., Boston KPro, guarded filtration), effective overall management remains challenging.