Liu Baiyun

Midgett Dan, Liu Baiyun, Ling Yik Tung Tracy, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

This study found that glaucoma eyes exhibit greater lamina cribrosa stiffness (lower strains) under pressure, with variations linked to the degree of axon damage, suggesting biomechanical changes contribute to or result from the disease.

Liu Baiyun, Kilpatrick Jason I, Lukasz Bartlomiej, Jarvis Suzanne P, McDonnell Fiona, Wallace Deborah M et al.

Studying human lamina cribrosa cells, researchers found stiffer environments activate myofibroblastic transformation, especially in glaucoma cells. This suggests mechanical changes drive optic nerve remodeling and fibrosis in glaucoma.

Liu Baiyun, McNally Sara, Kilpatrick Jason I, Jarvis Suzanne P, O'Brien Colm J

This review highlights how age-related ocular tissue stiffening, particularly in the trabecular meshwork and optic nerve head, contributes to glaucoma progression. Understanding these biomechanical changes offers new therapeutic targets.