Quigley Harry A

Vianna Jayme R, Quach Jack, Baek Sung-Uk, Quigley Harry A, Chauhan Balwantray C

Global experts defined glaucoma for research using visual fields and OCT. They found specific RNFL and Glaucoma Hemifield Test abnormalities offer 85-90% accuracy, providing a consensus-based research definition.

Czerpak Cameron A, Kashaf Michael Saheb, Zimmerman Brandon K, Mirville Rebecca, Gasquet Nicolas C, Quigley Harry A et al.

This study measured lamina cribrosa strain response to IOP elevation, finding glaucoma eyes showed distinct biomechanical changes. These strains correlate with glaucoma damage, suggesting a potential non-invasive biomarker for the disease.

Quillen Sarah E, Kimball Elizabeth C, Ritter-Gordy Kelsey A, Du Liya, Yuan Zhuochen, Pease Mary E et al.

Topical ripasudil reduced retinal ganglion cell loss in mouse glaucoma and optic nerve injury by suppressing ROCK signaling. This suggests a neuroprotective mechanism for RGCs and astrocytes.

Kanter Jacob A, Quigley Harry A

Quigley Harry A

Glaucoma screening faces ethical hurdles, leading to recommendations for improved patient follow-up and family screening as better care strategies.

Hannay Vanessa, Czerpak Cameron, Quigley Harry A, Nguyen Thao D

OCT measured lamina cribrosa strain changes after IOP lowering, revealing these strains are related to visual function loss, offering a non-invasive glaucoma assessment tool.

Korneva Arina, Kimball Elizabeth C, Johnson Thomas V, Quillen Sarah E, Pease Mary E, Quigley Harry A et al.

This study found glaucoma (high IOP) altered mouse astrocytic lamina mechanics, but optic nerve crush (axon damage) did not, suggesting IOP-induced changes, not just axon injury, affect lamina biomechanics.

Hong Seungwoo, Yang Hongli, Gardiner Stuart K, Luo Haomin, Sharpe Glen P, Caprioli Joseph et al.

This study found that optic nerve head remodeling in non-highly myopic eyes correlates with exposed scleral flange and thin choroid, suggesting implications for glaucoma risk, especially in high myopia.

Guan Carolyn, Pease Mary Ellen, Quillen Sarah, Ling Yik Tung Tracy, Li Ximin, Kimball Elizabeth et al.

Glaucoma significantly alters the optic nerve head, showing astrocyte migration into axonal bundles, changes in astrocyte structure, increased basement membrane, and thinning of connective tissue beams, contributing to nerve damage.

Quigley Harry A

Quigley Harry A, Stone Edwin M, Fingert John H

Montesano Giovanni, Quigley Harry A, Crabb David P

Selecting patients with low visual field test variability significantly improves the power of glaucoma neuroprotection trials, reducing the required sample size by up to 49%.

Szeto Julia, Chow Amanda, McCrea Liam, Mozzer Ann, Nguyen Thao D, Quigley Harry A et al.

This study found peripapillary sclera regions differ in cell density/morphology. Topography and TGFβ influence fibroblast response to mechanical strain, impacting scleral remodeling in glaucoma.

Ling Yik Tung Tracy, Pease Mary E, Jefferys Joan L, Kimball Elizabeth C, Quigley Harry A, Nguyen Thao D

Mouse optic nerve astrocytes showed significant structural changes, especially in unmyelinated regions, after 3 days of ocular hypertension, revealing early mechanotransduction relevant to glaucoma.

Midgett Dan, Liu Baiyun, Ling Yik Tung Tracy, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

This study found that glaucoma eyes exhibit greater lamina cribrosa stiffness (lower strains) under pressure, with variations linked to the degree of axon damage, suggesting biomechanical changes contribute to or result from the disease.

Quigley Harry A, Green W Richard

Iyer Jayant, Vianna Jayme R, Chauhan Balwantray C, Quigley Harry A

Experts are developing objective, standardized definitions for glaucomatous optic neuropathy (GON) using structural/functional data, excluding IOP. This aims to improve consistency and comparability across glaucoma research studies.

Ling Yik Tung Tracy, Shi Ran, Midgett Dan E, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

Studying human lamina cribrosa collagen, researchers found denser, more connected networks correlated with lower pressure-induced strain, potentially offering resistance to glaucomatous damage.

Quigley Harry A

Glaucoma care advances, emphasizing individualized IOP targets and improved adherence. New technologies like sustained drug delivery and surgical approaches are emerging but require rigorous testing.

Quigley Harry A

This study found transscleral cyclophotocoagulation for glaucoma is more successful when power is tailored to audible cues and higher total energy is delivered, rather than using standardized protocols.

Duan Xiangyun J, Jefferys Joan L, Quigley Harry A

Automated OCT segmentation of optic nerve head structures (BMO, LC) is comparable to human experts. This makes automated BMO analysis practical for glaucoma, despite some regional variability.

Johnson Thomas V, Ramulu Pradeep Y, Quigley Harry A, Singman Eric L

The Van Herick assessment poorly detects angle closure, even by experts, missing many cases and misclassifying others. Gonioscopy remains essential for accurate angle assessment.

Midgett Dan E, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

Removing sulfated GAGs stiffened human optic nerve tissue, reducing its pressure-induced strain. This suggests sGAGs influence LC biomechanics, potentially impacting glaucoma susceptibility and progression.

Liu Melissa M, Cho Chris, Jefferys Joan L, Quigley Harry A, Scott Adrienne W

Non-experts successfully used OCT for glaucoma screening; cup-to-disc ratio and inferior RNFL thickness showed robust diagnostic value, suggesting potential for community screening.

Flatau Alison, Solano Francisco, Jefferys Joan L, Damion Christopher, Quigley Harry A

A protective eye shield reduced limbal strain and its variability during face-down sleep in glaucoma patients, especially those with worsening vision, suggesting a simple way to mitigate potential ocular stress.