Midgett Dan E

🇴🇲 Johns Hopkins University Applied Physics Laboratory

2 articles in GJC

Characterizing the Collagen Network Structure and Pressure-Induced Strains of the Human Lamina Cribrosa.

Ling Yik Tung Tracy, Shi Ran, Midgett Dan E, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

Invest Ophthalmol Vis SciJun 201922 citationsBasic Science

Studying human lamina cribrosa collagen, researchers found denser, more connected networks correlated with lower pressure-induced strain, potentially offering resistance to glaucomatous damage.

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The Contribution of Sulfated Glycosaminoglycans to the Inflation Response of the Human Optic Nerve Head.

Midgett Dan E, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

Invest Ophthalmol Vis SciJun 201815 citationsBasic Science

Removing sulfated GAGs stiffened human optic nerve tissue, reducing its pressure-induced strain. This suggests sGAGs influence LC biomechanics, potentially impacting glaucoma susceptibility and progression.

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Midgett Dan E

Characterizing the Collagen Network Structure and Pressure-Induced Strains of the Human Lamina Cribrosa.

The Contribution of Sulfated Glycosaminoglycans to the Inflation Response of the Human Optic Nerve Head.