Jefferys Joan L

Ling Yik Tung Tracy, Pease Mary E, Jefferys Joan L, Kimball Elizabeth C, Quigley Harry A, Nguyen Thao D

Mouse optic nerve astrocytes showed significant structural changes, especially in unmyelinated regions, after 3 days of ocular hypertension, revealing early mechanotransduction relevant to glaucoma.

Midgett Dan, Liu Baiyun, Ling Yik Tung Tracy, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

This study found that glaucoma eyes exhibit greater lamina cribrosa stiffness (lower strains) under pressure, with variations linked to the degree of axon damage, suggesting biomechanical changes contribute to or result from the disease.

Ling Yik Tung Tracy, Shi Ran, Midgett Dan E, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

Studying human lamina cribrosa collagen, researchers found denser, more connected networks correlated with lower pressure-induced strain, potentially offering resistance to glaucomatous damage.

Duan Xiangyun J, Jefferys Joan L, Quigley Harry A

Automated OCT segmentation of optic nerve head structures (BMO, LC) is comparable to human experts. This makes automated BMO analysis practical for glaucoma, despite some regional variability.

Midgett Dan E, Jefferys Joan L, Quigley Harry A, Nguyen Thao D

Removing sulfated GAGs stiffened human optic nerve tissue, reducing its pressure-induced strain. This suggests sGAGs influence LC biomechanics, potentially impacting glaucoma susceptibility and progression.

Liu Melissa M, Cho Chris, Jefferys Joan L, Quigley Harry A, Scott Adrienne W

Non-experts successfully used OCT for glaucoma screening; cup-to-disc ratio and inferior RNFL thickness showed robust diagnostic value, suggesting potential for community screening.

Flatau Alison, Solano Francisco, Jefferys Joan L, Damion Christopher, Quigley Harry A

A protective eye shield reduced limbal strain and its variability during face-down sleep in glaucoma patients, especially those with worsening vision, suggesting a simple way to mitigate potential ocular stress.

Schaub Julie A, Kimball Elizabeth C, Steinhart Matthew R, Nguyen Cathy, Pease Mary E, Oglesby Ericka N et al.

Mouse glaucoma showed selective RGC axon loss, predominantly in superior and temporal optic nerve regions, mirroring human glaucoma patterns, suggesting strain-specific damage responses.

Nguyen Cathy, Midgett Dan, Kimball Elizabeth C, Steinhart Matthew R, Nguyen Thao D, Pease Mary E et al.

This study measured mouse optic nerve head and peripapillary sclera deformation under pressure. It found regional differences in how these tissues respond to acute and chronic IOP changes, providing insights into glaucoma's mechanical effects.

Solano-Moncada Francisco, Dymerska Malgorzata, Jefferys Joan L, Quigley Harry A

Glaucoma specialists often set target IOPs, but this varies by doctor and patient. When targets are missed, action is frequently taken, highlighting the need for consistent management to preserve vision.

Flatau Alison, Solano Francisco, Idrees Sana, Jefferys Joan L, Volpe Peter, Damion Christopher et al.

Simulated face-down sleep increased limbal strain in glaucoma eyes, especially those with worsening vision, suggesting mechanical stress contributes to damage.

Arora Karun S, Boland Michael V, Friedman David S, Jefferys Joan L, West Sheila K, Ramulu Pradeep Y

This study compared better-eye and integrated visual field mean deviation (MD) and their impact on visual disability. It found both MDs are similarly associated with disability, suggesting better-eye MD is a robust and simpler clinical measure.

Nguyen Cathy, Cone Frances E, Nguyen Thao D, Coudrillier Baptiste, Pease Mary E, Steinhart Matthew R et al.

This study found experimental glaucoma increased scleral stiffness in mice. CD1 mice, prone to ganglion cell loss, exhibited generalized scleral thinning and greater baseline strain, mimicking human glaucoma changes.

Ramulu Pradeep Y, Swenor Bonnielin K, Jefferys Joan L, Friedman David S, Rubin Gary S

Glaucoma patients read slower, especially during sustained silent reading where they also fatigue faster. This highlights significant daily reading challenges for glaucoma patients.

Arora Karun S, Jefferys Joan L, Maul Eugenio A, Quigley Harry A

This study found angle closure glaucoma eyes have significantly thicker choroids than open angle or normal eyes, suggesting choroidal expansion may contribute to angle closure disease development.

Arora Karun S, Jefferys Joan L, Maul Eugenio A, Quigley Harry A

Angle-closure eyes showed greater choroidal thickness increase and anterior chamber depth decrease after water drinking than open-angle eyes, suggesting choroidal dynamics may influence angle closure.

Solus Jason F, Jampel Henry D, Tracey Patricia A, Gilbert Donna L, Loyd Tara L, Jefferys Joan L et al.

Limbus-based and fornix-based trabeculectomy show similar success, but limbus-based yields higher, avascular blebs with more infections, while fornix-based has more hypotony and earlier cataracts.

Jampel Henry D, Solus Jason F, Tracey Patricia A, Gilbert Donna L, Loyd Tara L, Jefferys Joan L et al.

This study found trabeculectomy achieved target IOP in 70% of patients at 4 years, but commonly caused cataracts (55%) and had small risks of bleb-related issues (8.8%), informing patient counseling.