Fingert John H

Sekimitsu Sayuri, Ghazal Nabil, Aziz Kanza, Zhao Yan, Singh Rishabh K, Fingert John H et al.

This study found a low polygenic risk score (PRS) identifies ocular hypertensive individuals less likely to develop glaucoma over 20 years, suggesting PRS could help personalize risk assessment and treatment.

Scheetz Todd E, Tollefson Mallory R, Roos Ben R, Boese Erin A, Pouw Andrew E, Stone Edwin M et al.

This study found pathogenic *METTL23* gene variants in ~1% of normal-tension glaucoma patients, suggesting its role in this glaucoma subtype and offering a potential genetic marker for diagnosis.

Hehr Nicole, Barlow Patrick B, Najdawi Wisam, Reyes Arnulfo Garza, Boese Erin, Fingert John H et al.

Boese Erin A, Drack Arlene V, Roos Benjamin R, Alward Wallace L M, Tollefson Mallory R, Schnieders Michael J et al.

This study found a specific GJA3 gene variant causes congenital cataracts and a very high risk of glaucoma after cataract surgery, especially if performed early. Prophylactic retinal endolaser may reduce detachment risk.

Fox Austin R, Fingert John H

This review studied familial normal tension glaucoma genetics, finding specific gene mutations (OPTN, TBK1, MYOC) cause some cases, with OPTN-related NTG showing early onset and progression stabilized by very low IOP.

Boese Erin A, Alward Wallace L M, Kwon Young H, Roos Ben R, Stone Edwin M, Scheetz Todd E et al.

This study found THBS1 mutations are not a common cause of primary congenital glaucoma in a US population, suggesting they are a rare cause overall.

Quigley Harry A, Stone Edwin M, Fingert John H

Holm Elin, Holm Malan, Vilhelmsen Kaj, Andorsdottir Gudrid, Vorum Henrik, Simpson Allie et al.

This study found a 1.07% OAG prevalence in the Faroese population, but common glaucoma genes (MYOC, OPTN, TBK1) weren't implicated, suggesting unique genetic factors may contribute to their disease.

Fox Austin R, Alward Wallace L M, Fingert John H

A Down Syndrome patient developed aqueous misdirection after glaucoma surgery, suggesting this population's small eyes may increase surgical risk, requiring careful planning.

Quist Tyler S, Johnson Chris A, Robin Alan L, Fingert John H

This study found TBK1-associated glaucoma presents early with severe disease and slow-to-moderate progression, suggesting very low IOP targets may benefit these patients.

Tandon Anamika, Zhang Ze, Fingert John H, Kwon Young H, Wang Kai, Alward Wallace L M

Studying relatives of PDS/PG patients, this research found most cases are sporadic, with lower familial risk than thought. However, some families show clear autosomal dominant inheritance.

Fingert John H

Anderson Michael G, Meyer Kacie J, Hedberg-Buenz Adam, Fingert John H

Researchers reviewed animal models for Exfoliation Syndrome (XFS), finding engineered LOXL1 mice and naturally occurring B6-Lyst mice offer insights into XFS biology and potential drug testing.

DeLuca Adam P, Alward Wallace L M, Liebmann Jeffrey, Ritch Robert, Kawase Kazuhide, Kwon Young H et al.

Researchers studied TBK1 gene duplications/triplications in glaucoma patients, finding varied CNV borders often within repetitive DNA, suggesting mismatched recombination as the cause. This clarifies the genetic basis of some glaucoma cases.

Janson Ben J, Alward Wallace L, Kwon Young H, Bettis Daniel I, Fingert John H, Provencher Lorraine M et al.

Glaucoma, its treatments, and related factors damage corneal endothelial cells, impairing corneal clarity. Understanding this is crucial for preserving vision in glaucoma patients.

Guo Zhihui, Kwon Young H, Lee Kyungmoo, Wang Kai, Wahle Andreas, Alward Wallace L M et al.

This study found a new OCT-based algorithm (RGC-AC optimized) accurately predicts glaucoma visual field thresholds, performing nearly as well as the visual field test's own consistency, offering a promising diagnostic tool.

Miller Matthew A, Fingert John H, Bettis Daniel I

Glaucoma genetics research identified many genes/risk factors. Genetic testing, especially for juvenile glaucoma, can improve diagnosis, surveillance, and treatment, optimizing patient care.

Scheetz Todd E, Faga Ben, Ortega Lizette, Roos Ben R, Gordon Mae O, Kass Michael A et al.

This study found that TMCO1 genetic risk alleles significantly increased glaucoma risk in non-Hispanic whites, comparable to clinical predictors like intraocular pressure.

Risma Justin M, Tehrani Shandiz, Wang Kai, Fingert John H, Alward Wallace L M, Kwon Young H

This study found the Diaton tonometer has a large margin of error compared to Goldmann applanation tonometry in glaucoma and ocular hypertension patients. However, it may still be useful for keratoprosthesis patients lacking other objective IOP measurement options.

Pasquale Louis R, Borrás Terete, Fingert John H, Wiggs Janey L, Ritch Robert

This review highlighted that while new genetic risk factors for exfoliation syndrome (XFS) were identified, the precise mechanism of exfoliation material formation and its link to ocular disease remains unclear.

Christopher Mark, Abràmoff Michael D, Tang Li, Gordon Mae O, Kass Michael A, Budenz Donald L et al.

3D optic nerve head shape, derived from stereo photos, significantly improved prediction of primary open-angle glaucoma development in ocular hypertension, suggesting utility for early screening and genetic studies.

Munk Marion R, Simjanoski Evica, Fingert John H, Jampol Lee M

EDI-OCT in CODA patients revealed RPE and retinal tissue extending into the optic disc, a finding potentially unique to CODA and linked to myopia, improving our understanding of this anomaly.

Awadalla Mona S, Fingert John H, Roos Benjamin E, Chen Simon, Holmes Richard, Graham Stuart L et al.

TBK1 gene duplications/triplications were found in 1.2% of Australian normal-tension glaucoma patients, but not high-tension glaucoma, confirming TBK1's role in NTG etiology.

Fingert John H, Burden James H, Wang Kai, Kwon Young H, Alward Wallace L M, Anderson Michael G

This study found concentric iris transillumination defects, detected by infrared, are significantly more common and prominent in exfoliation syndrome. This offers a potential early diagnostic tool for XFS.

Davis Lea K, Meyer Kacie J, Schindler Emily I, Beck John S, Rudd Danielle S, Grundstad A Jason et al.

This study found rare copy number variations (CNVs) in POAG patients, absent in controls, suggesting these genetic changes contribute to glaucoma development and may offer future diagnostic targets.