Kass Michael A

Realini Tony, Balasubramani G K, Kenkre Tanya, Wolsk Jenny, Kass Michael A, Gazzard Gus et al.

The COAST trial compares standard versus low-energy SLT for new glaucoma/OHT. The abstract details the study design and baseline patient characteristics, showing a representative sample, which will clarify optimal SLT use for long-term glaucoma management.

Gordon Mae O, Gao Feng, Burkland John, Brandt James D, Huecker Julia B, Miller J Phillip et al.

Diagnosing primary open-angle glaucoma significantly reduced patients' mental health scores. Clinicians must acknowledge this impact and develop strategies to minimize patient distress.

Sekimitsu Sayuri, Ghazal Nabil, Aziz Kanza, Zhao Yan, Singh Rishabh K, Fingert John H et al.

This study found a low polygenic risk score (PRS) identifies ocular hypertensive individuals less likely to develop glaucoma over 20 years, suggesting PRS could help personalize risk assessment and treatment.

Singh Rishabh K, Zhao Yan, Elze Tobias, Fingert John, Gordon Mae, Kass Michael A et al.

Polygenic risk scores improved prediction of glaucoma onset in ocular hypertension patients, with higher scores indicating increased risk and earlier diagnosis, enhancing personalized risk stratification.

Leshno Ari, Bommakanti Nikhil, De Moraes Carlos Gustavo, Gordon Mae O, Kass Michael A, Cioffi George A et al.

This study found OHTN visual field progression primarily occurs in nasal and paracentral regions, consistent with known vulnerable disc areas. Monitoring these zones is crucial for early glaucoma detection and treatment efficacy.

Melchior Bruna, De Moraes C Gustavo, Paula Jayter S, Cioffi George A, Gordon Mae O, Kass Michael A et al.

This study found that 6-month visual field testing optimally detects glaucoma progression in high-risk ocular hypertension, while 12-month intervals suffice for low-risk patients, balancing detection with resource use.

Kass Michael A, Gordon Mae O

Kass Michael A, Heuer Dale K, Higginbotham Eve J, Parrish Richard K, Khanna Cheryl L, Brandt James D et al.

After 20 years, nearly half of OHTS participants developed POAG, but only one-fourth experienced visual field loss, aiding personalized ocular hypertension management decisions.

Gordon Mae O, Gao Feng, Huecker Julia Beiser, Miller J Philip, Margolis Mathew, Kass Michael A et al.

Studying ocular hypertension patients, long-term intraocular pressure variability was found not to significantly improve prediction of primary open-angle glaucoma development, suggesting existing models are sufficient.

Cousins Clara C, Pan Billy X, Chou Jonathan C, Shen Lucy Q, Gordon Mae O, Kass Michael A et al.

OHTS disc hemorrhages had densitometric profiles more similar to arterioles than venules, suggesting an arterial origin. This implies vascular dysregulation may contribute to glaucoma-related disc hemorrhages.

Brandt James D, Beiser Julia A, Kass Michael A, Gordon Mae O

OHTS found African Americans have significantly thinner corneas than Caucasians. This CCT difference impacts IOP measurement accuracy, crucial for glaucoma diagnosis and management.

Garcia Gian-Gabriel P, Lavieri Mariel S, Andrews Chris, Liu Xiang, Van Oyen Mark P, Kass Michael A et al.

Kalman filtering accurately forecasted visual field and IOP changes in OHTN patients over five years, potentially improving glaucoma risk assessment and personalized treatment decisions.

Gordon Mae O, Higginbotham Eve J, Heuer Dale K, Parrish Richard K, Robin Alan L, Morris Patricia A et al.

The OHTS-1 Endpoint Committee improved glaucoma incidence estimates and treatment effect calculations by 23%, highlighting its value in trials with co-morbidities.

Gordon Mae O, Kass Michael A

OHTS showed medication reduced glaucoma development in ocular hypertension patients, and a 5-factor model identifies high-risk individuals, guiding personalized treatment decisions.

Chou Jonathan C, Cousins Clara C, Miller John B, Song Brian J, Shen Lucy Q, Kass Michael A et al.

This study found glaucoma-related optic disc hemorrhages have densitometry similar to arterial macroaneurysms, not venous occlusions. This suggests an arterial origin for these hemorrhages, which could inform glaucoma pathophysiology.

Apte Rajendra S, Gordon Mae, Kass Michael A

Scheetz Todd E, Faga Ben, Ortega Lizette, Roos Ben R, Gordon Mae O, Kass Michael A et al.

This study found that TMCO1 genetic risk alleles significantly increased glaucoma risk in non-Hispanic whites, comparable to clinical predictors like intraocular pressure.

Christopher Mark, Abràmoff Michael D, Tang Li, Gordon Mae O, Kass Michael A, Budenz Donald L et al.

3D optic nerve head shape, derived from stereo photos, significantly improved prediction of primary open-angle glaucoma development in ocular hypertension, suggesting utility for early screening and genetic studies.

Gardiner Stuart K, Demirel Shaban, Gordon Mae O, Kass Michael A

This study found visual field sensitivity fluctuates seasonally, peaking in winter, independent of IOP changes. This suggests non-IOP factors influence glaucoma progression and impact monitoring.

Gardiner Stuart K, Demirel Shaban, De Moraes Carlos Gustavo, Liebmann Jeffrey M, Cioffi George A, Ritch Robert et al.

This study found that using shorter visual field series (6-9 tests) better detected glaucoma progression rate changes after treatment than using entire series, highlighting the importance of series length in monitoring.

Mansberger Steven L, Gordon Mae O, Jampel Henry, Bhorade Anjali, Brandt James D, Wilson Brad et al.

Cataract surgery in ocular hypertension patients significantly and durably lowers intraocular pressure (average 16.5% reduction), especially in those with higher baseline IOP, offering a therapeutic benefit beyond vision improvement.

De Moraes Carlos Gustavo, Demirel Shaban, Gardiner Stuart K, Liebmann Jeffrey M, Cioffi George A, Ritch Robert et al.

Treating ocular hypertension significantly slows visual field progression in OHTS observation patients, benefiting both converters and non-converters.

Brandt James D, Gordon Mae O, Gao Feng, Beiser Julia A, Miller J Phillip, Kass Michael A

Adjusting IOP for CCT doesn't improve glaucoma prediction models; using measured IOP and CCT separately is simpler and equally accurate for assessing risk.

Demirel Shaban, De Moraes Carlos Gustavo V, Gardiner Stuart K, Liebmann Jeffrey M, Cioffi George A, Ritch Robert et al.

This OHTS study found eyes developing glaucoma have significantly faster visual field deterioration, especially if both optic disc and VF worsen, highlighting progression risk for clinical management.

Bhorade Anjali M, Wilson Bradley S, Gordon Mae O, Palmberg Paul, Weinreb Robert N, Miller Eydie et al.

This study found that monocular trials are no better than independent eye testing for assessing glaucoma medication response, as neither adequately determines treatment efficacy due to high inter-eye IOP correlation.