Brandt James D

Gordon Mae O, Gao Feng, Burkland John, Brandt James D, Huecker Julia B, Miller J Phillip et al.

Diagnosing primary open-angle glaucoma significantly reduced patients' mental health scores. Clinicians must acknowledge this impact and develop strategies to minimize patient distress.

Gordon Mae O, Heuer Dale K, Higginbotham Eve J, Parrish Richard K, Liu Lei, Brandt James D et al.

OHTS found some glaucoma patients had rapid visual field loss despite follow-up, emphasizing careful monitoring and early treatment for ocular hypertensive patients at high risk.

Brandt James D, Shankar Suma P

Gedde Steven J, Feuer William J, Lim Kin Sheng, Barton Keith, Goyal Saurabh, Ahmed Iqbal I et al.

The PTVT study found trabeculectomy had more early complications than tube shunts for glaucoma. However, serious complications, late complications, and cataract progression were similar between groups over five years.

Gedde Steven J, Feuer William J, Lim Kin Sheng, Barton Keith, Goyal Saurabh, Ahmed Iqbal I et al.

This 5-year study found trabeculectomy and tube shunts similarly controlled IOP in primary glaucoma, but trabeculectomy required fewer medications, guiding surgical choice.

Brandt James D

A novel microshunt for refractory childhood glaucoma showed promising safety and efficacy, significantly lowering eye pressure in most patients, suggesting a viable alternative to traditional surgeries.

Kass Michael A, Heuer Dale K, Higginbotham Eve J, Parrish Richard K, Khanna Cheryl L, Brandt James D et al.

After 20 years, nearly half of OHTS participants developed POAG, but only one-fourth experienced visual field loss, aiding personalized ocular hypertension management decisions.

Nguyen Tran, Kim Han, Mielke Christy, Momont Anna C, Brandt James D, Liu Yao

Concurrent dexamethasone implant and glaucoma drainage device effectively controlled intraocular pressure and inflammation in uveitic glaucoma, offering a promising combined treatment approach for this complex condition.

Brandt James D, Beiser Julia A, Kass Michael A, Gordon Mae O

OHTS found African Americans have significantly thinner corneas than Caucasians. This CCT difference impacts IOP measurement accuracy, crucial for glaucoma diagnosis and management.

Lim Michele C, Hom Betty, Watnik Mitchell R, Brandt James D, Altman Allison R, Paul Tania et al.

This study found trabeculectomy outcomes using MMC injection or sponge were similar for IOP control. While sponge use had more late bleb complications, both techniques appeared comparable for glaucoma surgery.

Areaux Raymond G, Grajewski Alana L, Balasubramaniam Saranya, Brandt James D, Jun Amber, Edmunds Beth et al.

Trab360 trabeculotomy for childhood glaucoma showed good success (67.4%), especially for primary congenital glaucoma (81%), with few complications, making it an effective and safe treatment option.

Gedde Steven J, Feuer William J, Lim Kin Sheng, Barton Keith, Goyal Saurabh, Ahmed Iqbal I K et al.

Comparing tube shunts and trabeculectomy for uncontrolled glaucoma, both had similar 3-year failure rates. Trabeculectomy achieved lower IOP with fewer medications, but serious complications were similar for both procedures.

Weinreb Robert N, Liebmann Jeffrey M, Cioffi George A, Goldberg Ivan, Brandt James D, Johnson Chris A et al.

Two large studies found oral memantine (10mg or 20mg daily) did not prevent glaucoma progression over 48 months compared to placebo, indicating it's not an effective neuroprotective treatment.

Brandt James D

Vinod Kateki, Brandt James D, Gedde Steven J, Feuer William J, Shi Wei

Brandt James D, Sall Kenneth, DuBiner Harvey, Benza Robert, Alster Yair, Walker Gary et al.

A bimatoprost ocular insert safely reduced eye pressure similarly to timolol drops for six months. This offers a promising, adherence-improving alternative for glaucoma patients.

Okafor Kingsley C, Brandt James D

This review compared GAT with newer tonometers, finding no perfect device. Clinicians must choose carefully, considering accuracy, convenience, and cost, while remembering IOP is a variable snapshot.

Zangwill Linda M, Jain Sonia, Dirkes Keri, He Feng, Medeiros Felipe A, Trick Gary L et al.

This study found that eyes developing glaucoma lose optic disc rim area ~5 times faster than non-glaucomatous eyes, highlighting structural change rate as a key indicator for managing ocular hypertension.

Suhr Abraham W, Lim Michele C, Brandt James D, Izquierdo Juan Carlos, Willits Neil

This study found fornix-based and limbus-based conjunctival incisions for glaucoma drainage devices are equally effective in controlling IOP, suggesting either technique can be safely used.

Mansberger Steven L, Gordon Mae O, Jampel Henry, Bhorade Anjali, Brandt James D, Wilson Brad et al.

Cataract surgery in ocular hypertension patients significantly and durably lowers intraocular pressure (average 16.5% reduction), especially in those with higher baseline IOP, offering a therapeutic benefit beyond vision improvement.

Gedde Steven J, Herndon Leon W, Brandt James D, Budenz Donald L, Feuer William J, Schiffman Joyce C

This study compared complications of tube shunts vs. trabeculectomy for glaucoma. Trabeculectomy had more early complications, but late complications and reoperations were similar over five years, guiding surgical choice.

Gedde Steven J, Schiffman Joyce C, Feuer William J, Herndon Leon W, Brandt James D, Budenz Donald L

The TVT study found tube shunts had higher 5-year success and fewer reoperations than trabeculectomy with MMC for complex glaucoma, despite similar IOP control, suggesting tubes are a more durable option.

Mochizuki Hideki, Murphy Christopher J, Brandt James D, Kiuchi Yoshiaki, Russell Paul

Oxidative stress stabilizes IL-6 and IL-8 mRNAs in HTM cells, suggesting altered gene regulation in glaucoma progression. This mechanism could influence disease development.

Brandt James D, Gordon Mae O, Gao Feng, Beiser Julia A, Miller J Phillip, Kass Michael A

Adjusting IOP for CCT doesn't improve glaucoma prediction models; using measured IOP and CCT separately is simpler and equally accurate for assessing risk.

Mochizuki Hideki, Lesley Ashley G, Brandt James D

This study found that optic disc shrinkage (scleral canal) accompanies cupping reversal in children after glaucoma surgery, suggesting scleral elasticity plays a key role.