Kawase Kazuhide

Yamaguchi Katsuya, Tomita Ryo, Koyanagi Yoshito, Kawase Kazuhide, Asaoka Ryo, Terasaki Hiroko et al.

This study found cpRNFLT better for early glaucoma detection, but cpVD better for distinguishing severe stages. Combining both improves visual field estimation, aiding glaucoma management.

Inagaki Satoshi, Kawase Kazuhide, Funato Michinori, Seki Junko, Kawase Chizuru, Ohuchi Kazuki et al.

Timolol reduced optineurin aggregation and improved retinal ganglion cell survival in patient-derived glaucoma models, suggesting its potential as a targeted therapy for OPTNE50K normal-tension glaucoma.

DeLuca Adam P, Alward Wallace L M, Liebmann Jeffrey, Ritch Robert, Kawase Kazuhide, Kwon Young H et al.

Researchers studied TBK1 gene duplications/triplications in glaucoma patients, finding varied CNV borders often within repetitive DNA, suggesting mismatched recombination as the cause. This clarifies the genetic basis of some glaucoma cases.

Minegishi Yuriko, Nakayama Mao, Iejima Daisuke, Kawase Kazuhide, Iwata Takeshi

Studying OPTN E50K in glaucoma, researchers found amlexanox protected retinal ganglion cells in mice. This offers a potential therapy for normal tension glaucoma.

Inuzuka Hiroko, Kawase Kazuhide, Sawada Akira, Kokuzawa Satoko, Ishida Kyoko, Yamamoto Tetsuya

This study found that preperimetric glaucoma patients who developed visual field defects within three years had thinner macular and circumpapillary nerve layers, and higher IOP, emphasizing close monitoring.

Inuzuka Hiroko, Kawase Kazuhide, Sawada Akira, Aoyama Yumiko, Yamamoto Tetsuya

This study found macular retinal thinning corresponds to visual field defects in glaucoma, and also occurs in the *apparently normal* hemifield, suggesting structural loss precedes functional loss there.

Gao Yanlin, Sakurai Mayumi, Takeda Hisashi, Higashide Tomomi, Kawase Kazuhide, Sugiyama Kazuhisa

This study found specific adrenergic receptor gene variations are linked to different diurnal IOP levels in Japanese NTG patients, suggesting these genes may influence untreated IOP.

Shibuya Etsuko, Meguro Akira, Ota Masao, Kashiwagi Kenji, Mabuchi Fumihiko, Iijima Hiroyuki et al.

This study found specific variations in the TLR4 gene are associated with an increased risk of normal tension glaucoma, suggesting immune pathways may contribute to the disease.

Suemori Shinsuke, Shimazawa Masamitsu, Kawase Kazuhide, Satoh Masahiko, Nagase Hisamitsu, Yamamoto Tetsuya et al.

This study found that metallothionein, especially MT-II, protects retinal neurons from damage, suggesting that boosting its levels could be a therapeutic strategy for retinal neuroprotection.

Yamamoto Tetsuya, Iwase Aiko, Kawase Kazuhide, Sawada Akira, Ishida Kyoko

This study found optic disc hemorrhages, more prevalent in glaucoma, elderly, and females, often occur at normal intraocular pressure, highlighting their importance in glaucoma diagnosis/monitoring.

Alward Wallace L M, Kwon Young H, Kawase Kazuhide, Craig Jamie E, Hayreh Sohan S, Johnson A Tim et al.

This study found OPTN gene variations weren't broadly linked to open-angle glaucoma. Glu50Lys was rare in familial normal-tension glaucoma, while Met98Lys showed association in Japanese normal-tension glaucoma patients.