Kashiwagi Kenji

Mabuchi Fumihiko, Tanaka-Mabuchi Nakako, Sakurada Yoichi, Yoneyama Seigo, Yamagata Zentaro, Kashiwagi Kenji

In Japanese POAG patients, genetic variants linked to high eye pressure, but not optic nerve vulnerability, predicted a history of glaucoma surgery, suggesting their role in surgical need.

Ueno Yuta, Oda Masahiro, Yamaguchi Takefumi, Fukuoka Hideki, Nejima Ryohei, Kitaguchi Yoshiyuki et al.

An AI model diagnosed 36 cataract/corneal conditions from smartphone images with high accuracy (AUC >0.96 for most conditions), demonstrating its potential for remote diagnosis and triage in ophthalmology.

Danjo Yosuke, Shinozaki Youichi, Natsubori Akiyo, Kubota Yuto, Kashiwagi Kenji, Tanaka Kenji F et al.

The Mlc1 promoter was found to specifically target Müller cells in the retina, enabling precise genetic manipulation to study their role in ocular health and disease.

Mabuchi Fumihiko, Mabuchi Nakako, Sakurada Yoichi, Yoneyama Seigo, Kashiwagi Kenji, Iijima Hiroyuki et al.

This study found non-IOP genetic variants influence POAG onset (family history), while IOP-related variants impact progression (earlier diagnosis), suggesting distinct genetic pathways for these aspects.

Mabuchi Fumihiko, Mabuchi Nakako, Takamoto Mitsuko, Sakurada Yoichi, Yoneyama Seigo, Kashiwagi Kenji et al.

A genetic variant near PLXDC2 increases primary open-angle glaucoma risk in Japanese individuals by raising intraocular pressure, highlighting a genetic predisposition for higher IOP.

Asaoka Ryo, Murata Hiroshi, Fujino Yuri, Hirasawa Kazunori, Tanito Masaki, Mizoue Shiro et al.

This study found smoking is linked to visual field progression in all inferior glaucoma sectors, highlighting its importance as a modifiable risk factor for localized damage.

Kashiwagi Kenji, Kogure Satoshi, Mabuchi Fumihiko, Chiba Tatsuya, Yamamoto Tetsuya, Kuwayama Yasuaki et al.

This study found significant visual acuity loss in 12-28% of patients five years after MMC trabeculectomy, with poor preoperative vision, glaucoma subtype, and complications as key risk factors, informing patient counseling.

Fujino Yuri, Asaoka Ryo, Murata Hiroshi, Miki Atsuya, Tanito Masaki, Mizoue Shiro et al.

Studying glaucoma progression in a large Japanese database, researchers found age and baseline damage predict future worsening, while IOP fluctuation (not average IOP) was linked to faster progression.

Mabuchi Fumihiko, Sakurada Yoichi, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

Non-IOP genetic variants contribute to both HTG and NTG. A family history of glaucoma reflects the increased burden of these risk variants, aiding risk assessment.

Kashiwagi Kenji, Tanabe Naohiko, Go Kentaro, Imasawa Mitsuhiro, Mabuchi Fumihiko, Chiba Tetsuya et al.

This study found remote slit-lamp systems can effectively examine trabeculectomy eyes, similar to conventional methods, but take longer, while 2D photography was less accurate.

Kashiwagi Kenji, Ito Keisuke, Haniuda Hiroki, Ohtsubo Shinya, Takeoka Shinji

Latanoprost-loaded nanosheets delivered sustained IOP reduction for days with minimal side effects in rats, showing promise for extended glaucoma treatment and improved patient adherence.

Kashiwagi Kenji, Chiba Tatsuya, Mabuchi Fumihiko, Furuya Toshie, Tsukahara Shigeo

This 5-year study of Japanese adults found 5.4% developed angle closure, primarily in eyes with shallower anterior chambers and significant depth reduction, highlighting key risk factors.

Mabuchi Fumihiko, Sakurada Yoichi, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

This study found specific genetic variants (CDKN2B, ATOH7) are non-IOP-related risk factors for NTG, and CHEK2 for HTG, suggesting genetic contributions to glaucoma pathogenesis beyond VCDR.

Mabuchi Fumihiko, Yoshimura Kimio, Kashiwagi Kenji, Yamagata Zentaro, Kanba Shigenobu, Iijima Hiroyuki et al.

This study found younger glaucoma patients are more prone to anxiety, while older patients and those with worse vision are more susceptible to depression, highlighting age- and severity-specific mental health needs.

Pan Zhiying, Furuya Toshie, Kashiwagi Kenji

This study found anterior chamber depth and angle significantly decreased over five years in open-angle glaucoma patients, particularly peripherally, linking these changes to glaucoma progression.

Chang Dolly S, Sakata Lisandro M, Aung Tin, He Ming-Guang, Lavanya Raghavan, Kashiwagi Kenji et al.

Sequential testing with SPAC then AS-OCT significantly improved narrow angle detection accuracy (70.3% sensitivity at 94.3% specificity) compared to single tests, offering a better screening tool where ophthalmologists are limited.

Mabuchi Fumihiko, Sakurada Yoichi, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

SRBD1 gene polymorphism is linked to both normal-tension and high-tension glaucoma development. ELOVL5 polymorphism may indicate later-onset POAG, aiding risk assessment.

Mabuchi Fumihiko, Sakurada Yoichi, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

This study found specific ESR2 gene polymorphisms are associated with higher intraocular pressure in female primary open-angle glaucoma patients, suggesting a genetic link to IOP elevation in women.

Kashiwagi Kenji, Tsumura Toyoaki, Tsukahara Shigeo

Latanoprost monotherapy in Japanese glaucoma patients stably reduced intraocular pressure for 5 years, maintaining visual fields in ~70% of eyes, highlighting its long-term efficacy.

Lavanya Raghavan, Foster Paul J, Sakata Lisandro M, Friedman David S, Kashiwagi Kenji, Wong Tien-Yin et al.

This study found noncontact devices (SPAC, IOLMaster, AS-OCT) effectively detect narrow angles, but their low specificity limits their usefulness for broad population screening, despite good sensitivity.

Shibuya Etsuko, Meguro Akira, Ota Masao, Kashiwagi Kenji, Mabuchi Fumihiko, Iijima Hiroyuki et al.

This study found specific variations in the TLR4 gene are associated with an increased risk of normal tension glaucoma, suggesting immune pathways may contribute to the disease.

Mabuchi Fumihiko, Yoshimura Kimio, Kashiwagi Kenji, Shioe Kunihiko, Yamagata Zentaro, Kanba Shigenobu et al.

POAG patients showed significantly higher rates of anxiety and depression than controls. This highlights the need for clinicians to address mental health alongside glaucoma management.

Chiba Tatsuya, Chiba Nami, Kashiwagi Kenji

This study found systemic arterial stiffness was not strongly associated with glaucoma, suggesting it may not be a primary factor in its development or progression.

Kashiwagi Kenji, Tsukahara Shigeo

A new device (SPAC) helped nonphysicians identify individuals at risk for angle closure glaucoma in public health screenings, improving early detection and prevention of this blinding condition.

Baskaran Mani, Oen Francis T S, Chan Yiong-Huak, Hoh Sek-Tien, Ho Ching-Lin, Kashiwagi Kenji et al.

This study found the SPAC device correlated well with van Herick grading for anterior chamber depth but overestimated narrow angles compared to gonioscopy, suggesting caution in its clinical interpretation.