Mabuchi Fumihiko

Mabuchi Fumihiko, Tanaka-Mabuchi Nakako, Sakurada Yoichi, Yoneyama Seigo, Yamagata Zentaro, Kashiwagi Kenji

In Japanese POAG patients, genetic variants linked to high eye pressure, but not optic nerve vulnerability, predicted a history of glaucoma surgery, suggesting their role in surgical need.

Mabuchi Fumihiko, Mabuchi Nakako, Sakurada Yoichi, Yoneyama Seigo, Kashiwagi Kenji, Iijima Hiroyuki et al.

This study found non-IOP genetic variants influence POAG onset (family history), while IOP-related variants impact progression (earlier diagnosis), suggesting distinct genetic pathways for these aspects.

Mabuchi Fumihiko, Mabuchi Nakako, Takamoto Mitsuko, Sakurada Yoichi, Yoneyama Seigo, Kashiwagi Kenji et al.

A genetic variant near PLXDC2 increases primary open-angle glaucoma risk in Japanese individuals by raising intraocular pressure, highlighting a genetic predisposition for higher IOP.

Kashiwagi Kenji, Kogure Satoshi, Mabuchi Fumihiko, Chiba Tatsuya, Yamamoto Tetsuya, Kuwayama Yasuaki et al.

This study found significant visual acuity loss in 12-28% of patients five years after MMC trabeculectomy, with poor preoperative vision, glaucoma subtype, and complications as key risk factors, informing patient counseling.

Mabuchi Fumihiko, Sakurada Yoichi, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

Non-IOP genetic variants contribute to both HTG and NTG. A family history of glaucoma reflects the increased burden of these risk variants, aiding risk assessment.

Kashiwagi Kenji, Tanabe Naohiko, Go Kentaro, Imasawa Mitsuhiro, Mabuchi Fumihiko, Chiba Tetsuya et al.

This study found remote slit-lamp systems can effectively examine trabeculectomy eyes, similar to conventional methods, but take longer, while 2D photography was less accurate.

Kashiwagi Kenji, Chiba Tatsuya, Mabuchi Fumihiko, Furuya Toshie, Tsukahara Shigeo

This 5-year study of Japanese adults found 5.4% developed angle closure, primarily in eyes with shallower anterior chambers and significant depth reduction, highlighting key risk factors.

Mabuchi Fumihiko, Sakurada Yoichi, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

This study found specific genetic variants (CDKN2B, ATOH7) are non-IOP-related risk factors for NTG, and CHEK2 for HTG, suggesting genetic contributions to glaucoma pathogenesis beyond VCDR.

Mabuchi Fumihiko, Yoshimura Kimio, Kashiwagi Kenji, Yamagata Zentaro, Kanba Shigenobu, Iijima Hiroyuki et al.

This study found younger glaucoma patients are more prone to anxiety, while older patients and those with worse vision are more susceptible to depression, highlighting age- and severity-specific mental health needs.

Mabuchi Fumihiko, Sakurada Yoichi, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

SRBD1 gene polymorphism is linked to both normal-tension and high-tension glaucoma development. ELOVL5 polymorphism may indicate later-onset POAG, aiding risk assessment.

Mabuchi Fumihiko, Sakurada Yoichi, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

This study found specific ESR2 gene polymorphisms are associated with higher intraocular pressure in female primary open-angle glaucoma patients, suggesting a genetic link to IOP elevation in women.

Shibuya Etsuko, Meguro Akira, Ota Masao, Kashiwagi Kenji, Mabuchi Fumihiko, Iijima Hiroyuki et al.

This study found specific variations in the TLR4 gene are associated with an increased risk of normal tension glaucoma, suggesting immune pathways may contribute to the disease.

Mabuchi Fumihiko, Yoshimura Kimio, Kashiwagi Kenji, Shioe Kunihiko, Yamagata Zentaro, Kanba Shigenobu et al.

POAG patients showed significantly higher rates of anxiety and depression than controls. This highlights the need for clinicians to address mental health alongside glaucoma management.

Mabuchi Fumihiko, Tang Sa, Kashiwagi Kenji, Yamagata Zentaro, Iijima Hiroyuki, Tsukahara Shigeo

OPA1 gene polymorphism IVS 8+32 T/C is linked to increased normal tension glaucoma risk and earlier high tension glaucoma onset, suggesting its role as a genetic risk marker for both.

Mabuchi Fumihiko, Aihara Makoto, Mackey Mason R, Lindsey James D, Weinreb Robert N

Mouse experimental glaucoma showed preferential superior optic nerve axon loss, suggesting regional vulnerability to damage. This highlights the importance of topographic assessment in glaucoma research.

Mabuchi Fumihiko, Lindsey James D, Aihara Makoto, Mackey Mason R, Weinreb Robert N

This study found transgenic mice with a type I collagen mutation develop sustained elevated IOP and progressive optic nerve axon loss, making them a useful model for primary open-angle glaucoma research.

Mabuchi Fumihiko, Aihara Makoto, Mackey Mason R, Lindsey James D, Weinreb Robert N

This mouse study found that laser-induced ocular hypertension causes optic nerve axon loss correlating with IOP magnitude/duration, highlighting pressure's role in glaucoma pathology.