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The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy.
Quillen Sarah E, Kimball Elizabeth C, Ritter-Gordy Kelsey A, Du Liya, Yuan Zhuochen, Pease Mary E et al.
Invest Ophthalmol Vis SciNov 20246 citationsBasic Science
Topical ripasudil reduced retinal ganglion cell loss in mouse glaucoma and optic nerve injury by suppressing ROCK signaling. This suggests a neuroprotective mechanism for RGCs and astrocytes.