McLaren Jay W

Kazemi Arash, McLaren Jay W, Sit Arthur J

Topical phenylephrine's effect on episcleral venous pressure (EVP) and intraocular pressure (IOP) was studied. While IOP increased, EVP decreased, indicating IOP elevation isn't due to increased EVP, a clinically relevant finding for glaucoma management.

Kazemi Arash, McLaren Jay W, Trese Matthew G J, Toris Carol B, Gulati Vikas, Fan Shan et al.

Timolol, a common glaucoma medication, was found to decrease aqueous humor outflow facility in healthy eyes, potentially impacting long-term trabecular meshwork health, warranting further investigation into its mechanism.

Sit Arthur J, Lin Shuai-Chun, Kazemi Arash, McLaren Jay W, Pruet Christopher M, Zhang Xiaoming

USWE noninvasively measured corneal elasticity in healthy eyes, finding it correlated with IOP. This novel method could help understand glaucoma risk by assessing ocular biomechanics.

Kazemi Arash, McLaren Jay W, Lin Shuai-Chun, Toris Carol B, Gulati Vikas, Moroi Sayoko E et al.

Comparing pneumatonography and Schiøtz tonography for outflow facility, researchers found they correlated but yielded different absolute values (Schiøtz higher), meaning they are not interchangeable for direct clinical comparison.

Nau Cherie B, Malihi Mehrdad, McLaren Jay W, Hodge David O, Sit Arthur J

This study found that stable nocturnal IOP, despite reduced aqueous humor flow, is maintained by decreased outflow facility and a significant reduction in uveoscleral outflow, crucial for understanding glaucoma management.

Lim K Sheng, Nau Cherie B, O'Byrne Megan M, Hodge David O, Toris Carol B, McLaren Jay W et al.

This study found bimatoprost, latanoprost, and travoprost similarly lower IOP in healthy subjects by increasing aqueous outflow, with the specific outflow pathway identified depending on the measurement method.

Sit Arthur J, Nau Cherie B, McLaren Jay W, Johnson Douglas H, Hodge David

This study found that in healthy adults, nocturnal intraocular pressure decreased only slightly despite a significant drop in aqueous humor flow, implying other factors like episcleral venous pressure or uveoscleral outflow are crucial for nocturnal IOP regulation.

Christiansen Gregory A, Nau Cherie B, McLaren Jay W, Johnson Douglas H

Bimatoprost lowers eye pressure in glaucoma patients by significantly increasing aqueous outflow through both pressure-sensitive and pressure-insensitive pathways, without affecting aqueous production.

McLaren Jay W, Herman David C, Brubaker Richard F, Nau Cherie B, Wayman Laura L, Ciarniello Maria Grazia et al.

This study found ibopamine increases aqueous humor production in healthy eyes, even when controlling for pupil dilation. This unique effect may influence intraocular pressure.