Narumiya Shuh

Ota Takashi, Aihara Makoto, Saeki Tadashiro, Narumiya Shuh, Araie Makoto

Tafluprost lowers eye pressure mainly through the FP receptor, with some effect also involving FP-mediated prostaglandin production acting on the EP3 receptor, important for glaucoma treatment.

Ota Takashi, Aihara Makoto, Saeki Tadashiro, Narumiya Shuh, Araie Makoto

This study found that prostaglandin analogues lower IOP in mice, with EP1 and EP2 receptors not being crucial, but EP3 receptors potentially contributing to their IOP-lowering effect.

Ota Takashi, Aihara Makoto, Narumiya Shuh, Araie Makoto

Studying FP-receptor-deficient mice showed prostaglandin analogues require this receptor for IOP lowering. This confirms the FP receptor's crucial role in their clinical efficacy for glaucoma treatment.