Saeki Tadashiro

Kuroda Kohei, Hayashi Yusuke, Asaoka Satoko, Komori Tsubasa, Asada Yosuke, Iwamoto Satoshi et al.

Ahmed Glaucoma Valve implantation into the ciliary sulcus offers similar eye pressure control to anterior chamber placement, with less corneal damage, despite more surgical difficulty and hyphema.

Saeki Tadashiro, Koutari Sawako, Hayashi Takahiko, Yokota Harumasa, Yamagami Satoru, Mackool Richard

This study found a modified Yamane technique for scleral IOL fixation yielded good outcomes and stable refractive predictability, making it easier to master.

Mayama Chihiro, Ishii Kiyoshi, Saeki Tadashiro, Ota Takashi, Tomidokoro Atsuo, Araie Makoto

This monkey study found phenylephrine reduced ONH blood flow in normal eyes, while tafluprost increased it in both normal and glaucomatous eyes, suggesting differential drug effects on ONH circulation.

Saeki Tadashiro, Ota Takashi, Aihara Makoto, Araie Makoto

This study found EP2 and EP4 receptor agonists effectively lower mouse IOP, suggesting these pathways are promising targets for new glaucoma medications, distinct from current prostaglandin analogs.

Sasaki Takaaki, Watanabe Wataru, Muranishi Yuki, Kanamoto Takashi, Aihara Makoto, Miyazaki Kazuko et al.

ODAG overexpression in mice caused elevated intraocular pressure, optic nerve atrophy, and impaired retinal development, suggesting a new model for ocular hypertension and developmental defects.

Ota Takashi, Aihara Makoto, Saeki Tadashiro, Narumiya Shuh, Araie Makoto

Tafluprost lowers eye pressure mainly through the FP receptor, with some effect also involving FP-mediated prostaglandin production acting on the EP3 receptor, important for glaucoma treatment.

Ota Takashi, Aihara Makoto, Saeki Tadashiro, Narumiya Shuh, Araie Makoto

This study found that prostaglandin analogues lower IOP in mice, with EP1 and EP2 receptors not being crucial, but EP3 receptors potentially contributing to their IOP-lowering effect.