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ALK5 Inhibition of Subconjunctival Scarring From Glaucoma Surgery: Effects of SB-431542 Compared to Mitomycin C in Human Tenon's Capsule Fibroblasts.
Teplitsky Jack E, Vinokurtseva Anastasiya, Armstrong James J, Denstedt James, Liu Hong, Hutnik Cindy M L
Transl Vis Sci TechnolFeb 20235 citationsBasic Science
This study found the TGFβ1 inhibitor SB-431542 effectively reduced scarring in human eye cells, similar to Mitomycin C, but with significantly less toxicity, suggesting a safer antifibrotic for glaucoma surgery.