Xin Chen

Fellman Ronald L, Padilla Steven, Liu Avery, Holliman Matthew, Xin Chen, Martin Elizabeth et al.

Clinical OCT revealed valvelike structures in Schlemm canal, correlating with known ex vivo anatomy. This bridges lab findings to living human outflow, enhancing our understanding of glaucoma.

Yin Peng, Li Jiaying, Shi Yan, Cao Kai, Han Ying, Wang Huaizhou et al.

This study compared two glaucoma surgeries, finding GATT achieved better IOP reduction than ABiC for open-angle glaucoma patients, offering a potentially more effective surgical option.

Shi Yan, Wang Huaizhou, Oatts Julius T, Xin Chen, Yin Peng, Zhang Li et al.

GATT effectively treats JOAG, but older age and prolonged postoperative IOP spikes predict surgical failure, highlighting the need for careful early IOP monitoring.

Sui Shangru, Yu Hongxia, Wang Xiangji, Wang Wenyan, Yang Xuejiao, Pan Xiaojing et al.

iPSC-derived TM cells stimulate native TM cell division and restore function in glaucoma models via gap junctions, especially Cx43. This reveals a key mechanism to enhance regenerative glaucoma therapies.

Wang Yiwei, Wang Huaizhou, Han Ying, Shi Yan, Xin Chen, Yin Peng et al.

GATT effectively lowered IOP and medication dependence in juvenile-onset primary open-angle glaucoma, showing promise even for severe cases or those with prior surgery.

Johnstone Murray, Xin Chen, Tan James, Martin Elizabeth, Wen Joanne, Wang Ruikang K

This model proposes that trabecular meshwork elasticity drives a pump-like outflow system, failing in glaucoma. Understanding this offers novel diagnostics (like OCT) and therapies for improved patient care.

Shi Yan, Wang Huaizhou, Oatts Julius, Cao Kai, Xin Chen, Liang Xintong et al.

This study found ab interno and ab externo microcatheter trabeculotomy yield comparable, good outcomes for primary congenital glaucoma with clear corneas, suggesting ab interno is a valid initial choice, preserving conjunctiva.

Xin Chen, Wang Huangzhou, Wang Ningli

This review summarized a session on new MIGS techniques, highlighting diverse options for aqueous outflow recovery and identifying key areas for future research in glaucoma.

Zhang Qing, Zhang Ye, Xin Chen, Mao Yingyan, Cao Kai, Jan Catherine et al.

This study found higher eye pressure and narrower retinal arterioles independently predict deeper optic cup depth, which helps understand glaucoma risk.

Shi Yan, Wang Huaizhou, Han Ying, Cao Kai, Vu Vivian, Hu Man et al.

UBM-graded trabeculodysgenesis in congenital glaucoma correlated with surgical success, showing severe types had worse MAT outcomes. This helps predict MAT prognosis and guide treatment.

Xin Chen, Song Shaozhen, Johnstone Murray, Wang Ningli, Wang Ruikang K

PhS-OCT showed the trabecular meshwork pulsates, with greater motion externally, and increases with accommodation. This provides insight into TM function and potential glaucoma management.

Wang Ke, Johnstone Murray A, Xin Chen, Song Shaozhen, Padilla Steven, Vranka Janice A et al.

This study estimated human trabecular meshwork stiffness. Glaucomatous tissue was slightly stiffer, and stiffness correlated with outflow facility, suggesting TM biomechanics influence glaucoma.

Chen Chieh-Li, Bojikian Karine D, Wen Joanne C, Zhang Qinqin, Xin Chen, Mudumbai Raghu C et al.

This study found reduced peripapillary retinal nerve fiber layer microcirculation in both affected and clinically "normal" hemispheres of glaucoma eyes, suggesting vascular dysfunction may precede structural changes.

Xin Chen, Chen Xiaoya, Li Meng, Shi Yan, Wang Huaizhou, Wang Ruikang et al.

A new intraocular SS-OCT probe successfully imaged collector channel entrances in cadaver eyes, demonstrating its potential to assist glaucoma surgery by visualizing outflow structures.

Xin Chen, Chen Xiaoya, Shi Yan, Wang Huaizhou, Wang Ningli

Modified canaloplasty effectively lowered eye pressure and medication use in glaucoma patients with prior surgical Schlemm's canal disruption, showing promise for these challenging cases.

Chen Chieh-Li, Zhang Anqi, Bojikian Karine D, Wen Joanne C, Zhang Qinqin, Xin Chen et al.

OMAG revealed reduced peripapillary RNFL microcirculation (blood flux index) in glaucoma and suspects, correlating with structural/functional damage. This may aid glaucoma monitoring.

Xin Chen, Chen Xiaoya, Shi Yan, Li Meng, Wang Huaizhou, Wang Ningli

Canaloplasty effectively lowered eye pressure and medication use in POAG patients, even after failed prior glaucoma surgery, provided Schlemm's canal was intact, offering a safe treatment option.

Shi Yan, Wang Huaizhou, Yin Jia, Li Meng, Zhang Xifang, Xin Chen et al.

Microcatheter-assisted trabeculotomy for childhood glaucoma showed superior early IOP reduction and success rates compared to rigid probe methods, suggesting it's a safer, more effective treatment option.